婴儿牛奶蛋白过敏的危险因素:一项多中心前瞻性巢式病例对照研究  

Risk factors for cow's milk protein allergy in infants: a multicenter prospectivenested case-control study

作　　者：侯林 马紫君 晁爽 李中原[3] 张宇 刘毅坚[5] 张俊红 武文艳[7] 黄山雅美[1] 刘捷[1] HOU Lin;MA Zi-Jun;CHAO Shuang;LI Zhong-Yuan;ZHANG Yu;LIU Yi-Jian;ZHANG Jun-Hong;WU Wen-Yan;HUANG Shan-Ya-Mei;LIU Jie(Department of Pediatrics,Peking University People's Hospital,Peking University,Beijing 100044,China)

机构地区：[1]北京大学人民医院儿科,北京100044 [2]清华大学附属北京清华长庚医院儿科,北京102218 [3]解放军总医院第四医学中心儿科,北京100089 [4]北京市通州区妇幼保健院儿科,北京101101 [5]北京丰台医院儿科,北京100070 [6]空军特色医学中心儿科,北京100142 [7]北京华信医院(清华大学第一附属医院)儿科,北京100016

出　　处：《中国当代儿科杂志》2024年第3期230-235,共6页Chinese Journal of Contemporary Pediatrics

基　　金：北京市临床重点专科项目(2018)(2199000726)。

摘　　要：目的探讨婴儿牛奶蛋白过敏(cow'smilkproteinallergy,CMPA)发生的危险因素。方法该研究为多中心前瞻性巢式病例对照研究。选取北京市7家医学中心0~12月龄婴儿为研究对象。共纳入CMPA婴儿200例,未发生CMPA的婴儿(对照组)799例。采用单因素和多因素logistic回归分析探讨CMPA发生的危险因素。结果单因素logistic回归分析显示,早产儿、低出生体重儿、第一胎、第一产、春季出生、夏季出生、混合/人工喂养、父母患过敏性疾病与婴儿CMPA患病风险增加有关(P<0.05)。多因素logistic回归分析显示,第一产(OR=1.89,95%CI:1.14~3.13)、春季出生(OR=3.42,95%CI:1.70~6.58)、夏季出生(OR=2.29,95%CI:1.22~4.27)、混合/人工喂养(OR=1.57,95%CI:1.10~2.26)、父亲或母亲有过敏史(OR=2.13,95%CI:1.51~3.02)、双亲有过敏史(OR=3.15,95%CI:1.78~5.56)是婴儿CMPA发生的危险因素(P<0.05)。结论第一产出生、春季出生、夏季出生、混合/人工喂养或有过敏家族史的婴儿CMPA的患病风险增加。Objective To explore the risk factors associated with cow's milk protein allergy(CMPA)in infants.Methods This study was a multicenter prospective nested case-control study conducted in seven medical centers in Beijing,China.Infants aged 0-12 months were included,with 200 cases of CMPA infants and 799 control infants without CMPA.Univariate and multivariate logistic regression analyses were used to investigate the risk factors for the occurrence of CMPA.Results Univariate logistic regression analysis showed that preterm birth,low birth weight,birth from the first pregnancy,firstborn,spring birth,summer birth,mixed/artificial feeding,and parental history of allergic diseases were associated with an increased risk of CMPA in infants(P<0.05).Multivariate logistic regression analysis revealed that firstborn(OR=1.89,95%CI:1.14-3.13),spring birth(OR=3.42,95%CI:1.70-6.58),summer birth(OR=2.29,95%CI:1.22-4.27),mixed/artificial feeding(OR=1.57,95%CI:1.10-2.26),parental history of allergies(OR=2.13,95%CI:1.51-3.02),and both parents having allergies(OR=3.15,95%CI:1.78-5.56)were risk factors for CMPA in infants(P<0.05).Conclusions Firstborn,spring birth,summer birth,mixed/artificial feeding,and a family history of allergies are associated with an increased risk of CMPA in infants.

关 键 词：牛奶蛋白过敏 危险因素 食物过敏 婴儿 

分 类 号：R174[医药卫生—妇幼卫生保健]