中药调控NF-κB信号通路干预椎间盘退行性变的作用机制  

Mechanism of Traditional Chinese Medicine Intervention in IntervertebralDisc Degeneration by Regulating NF- κB Signaling Pathway

作　　者：谢芋涛 王想福[2] 石瑞芳[2] 李晨旭[2] 陈伟国 杨焕莹 张万乾 杨建霞 陶瑜晶 任毅 XIE Yutao;WANG Xiangfu;SHI Ruifang;LI Chenxu;CHEN Weiguo;YANG Huanying;ZHANG Wanqian;YANG Jianxia;TAO Yujing;REN Yi(Gansu University of Chinese Medicine,Lanzhou Gansu China 730000;Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou Gansu China 730050)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]甘肃省中医院,甘肃兰州730050

出　　处：《中医学报》2024年第4期737-742,共6页Acta Chinese Medicine

基　　金：甘肃省自然科学基金项目(21JR1RA058);兰州市科技发展计划项目(2020-ZD-36);兰州市人才创新创业项目(2020-RC-54)。

摘　　要：核因子-κB(nuclear factor-kappa B,NF-κB)信号通路是介导椎间盘炎症反应发生的重要通路之一。中药可以不同程度干预NF-κB信号通路的活化,阻断细胞中IκBα磷酸化,减少p65的核转移,下调促炎因子的大量释放,减轻炎症反应,从而降低基质降解酶的表达,使聚集蛋白多糖和Ⅱ型胶原的表达基本恢复到正常水平,抑制髓核细胞凋亡,改善椎间盘代谢的紊乱,达到保护椎间盘、治疗椎间盘退行性变的目的。Nuclear factor-kappa B(NF-κB)signaling pathway is one of the important pathways that mediate the inflammatory response of intervertebral discs.Traditional Chinese medicine can intervene in the activation of NF-κB signaling pathway to varying degrees,block IκBαphosphorylation in cells,reduce nuclear metastasis of P65,downregulate the release of pro-inflammatory factors,alleviate inflammatory response,thus reduce the expression of matrix degrading enzymes,restore the expression of aggregation protein polysaccharides and typeⅡcollagen to normal levels,inhibit apoptosis of nucleus pulposus cells,improve metabolic disorders of intervertebral discs,and achieve the goal of protecting intervertebral discs and treating intervertebral disc degeneration.

关 键 词：椎间盘退行性变 NF-ΚB信号通路 中药 

分 类 号：R285.6[医药卫生—中药学]