功能磁共振成像在移植肾功能评估中的应用进展  

Research advances on the applications of functional magnetic resonance imaging for evaluating kidney transplant function

作　　者：李文鑫 张军[2] 高峰[2] 甘甜 Li Wenxin;Zhang Jun;Gao Feng;Gan Tian(Department of Imaging Medicine,Third Affiliated Clinical College,Inner Mongolia Medical University,Baotou 014010,China;Department of Imaging Medicine,Inner Mongolia Baogang Hospital,Baotou 014010,China)

机构地区：[1]内蒙古医科大学第三临床医学院影像医学部,包头014010 [2]内蒙古包钢医院影像医学部,包头014010

出　　处：《中华器官移植杂志》2024年第1期57-61,共5页Chinese Journal of Organ Transplantation

摘　　要：肾移植术后及时发现移植肾功能变化,可以指导临床管理治疗,从而预防或延缓移植肾的不可逆损害。移植肾的功能磁共振成像(functional magnetic resonance imaging,fMRI)是具有良好临床应用前景的非侵入性检查技术,可以显示移植肾的微观结构和微功能信息。近年来,多种扩散成像、动脉自旋标记、血氧水平依赖磁共振成像等技术已逐步应用于移植肾功能评估,从移植肾水分子扩散、血流灌注及血氧水平等微观角度对移植肾功能进行无创评估。本文就多种fMRI技术在评估移植肾功能和鉴别移植肾功能减退原因等中的应用情况做综述,以期为临床诊断提供新思路。After kidney transplantation,timely detection of changes in transplanted kidney function may guide clinical managements and prevent or delay irreversible damage to transplanted kidney.Functional magnetic resonance imaging(fMRI)of transplanted kidney is a promising non-invasive technique of acquiring microstructural and microfunctional profiles of transplanted kidney.In recent years,various diffusion imaging modalities,arterial spin labeling(ASL)and blood oxygen level dependent-magnetic resonance imaging(BOLD-MRI)have gradually been applied for transplant kidneys.Transplant kidney function may be evaluated non-invasively from such microscopic perspectives as water molecule diffusion,blood flow perfusion and blood oxygen level.This review focused upon evaluating the renal function and identifying the causes of the renal function decline of transplanted kidney through various fMRI techniques and provide new rationales for clinical diagnosis.

关 键 词：功能磁共振成像 肾移植 移植肾功能 体素内不相干运动 弥散张量成像 动脉自旋标记 血氧水平依赖磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R699.2[医药卫生—诊断学]