集体养老人群中微量白蛋白尿与24 h尿钠、尿钾及钠钾比相关性研究  

A study on the correlation between microalbuminuria and 24 h urine sodium,urine potassium and the ratio of sodium to potassium among people in elderly care facilities

作　　者：段培芬 郝嘉琪 原建慧 冯向先 DUAN Pei-fen;HAO Jia-qi;YUAN Jian-hui;FENG Xiang-xian(Department of Preventive Medicine,Changzhi Medical College,Changzhi,Shanxi 046000,China;不详)

机构地区：[1]长治医学院公共卫生与预防医学系,山西长治046000 [2]长治医学院第二临床学院

出　　处：《现代预防医学》2024年第6期1094-1098,共5页Modern Preventive Medicine

基　　金：国家重点研发计划项目(2016YFC1300200-3)。

摘　　要：目的了解集体养老人群24 h尿钠、尿钾、钠钾比与微量白蛋白尿(microalbuminuria,MAU)的关系。方法采用随机整群抽样方法于2017年9月至2017年11月在山西省东南部地区16家养老机构进行问卷调查、体格检查、血液及24 h尿液标本收集。采用多因素非条件logistic回归分析24 h尿钠、尿钾、钠钾比与微量白蛋白尿的相关性。结果本次纳入研究对象502人,平均年龄为65.77±8.54岁,男性467人(93.03%),24小时尿钠、尿钾、钠钾比分别为(193.02±87.64)mmol、(27.95±15.02)mmol、(7.44±2.62),MAU者33人(6.57%);多因素logistic回归分析显示:较高的24 h尿钠与钠钾比水平(Q4)与最低水平(Q1)相比,MAU的发生风险增加(OR=4.026,95%CI:1.045~15.515;OR=4.043,95%CI:1.252~13.057)。结论MAU的发生与24 h尿钠、钠钾比呈正相关,而与24 h尿钾无关。Objective To investigate the relationship between 24-hour urinary sodium,urinary potassium,sodium-potassium ratio and microalbuminuria among people in elderly care institutions.Methods Questionnaire survey,physical examination,blood and 24 h urine samples collection were carried out in the elderly people of 16 elderly care institutions in southeastern Shanxi from September 2017 to November 2017,which were selected using the random cluster sampling method.A multivariate logistic regression model was used to analyze the association between 24 h urinary sodium excretion,urinary potassium excretion,sodium-potassium ratio and MAU.Results A total of 502 subjects including 467 males(93.03%)and 33 MAU(6.57%)were included in this study(average age:65.77±8.54 years old).The 24 h urinary sodium excretion was(193.02±87.64)mmol,urinary potassium excretion was(27.95±15.02)mmol,and the sodium-potassium ratio was(7.44±2.62),respectively.Multivariate logistic regression analysis showed that group with the highest urinary sodium excretion and the sodium-potassium ratio(Q4)compared to the lowest group(Q1)was associated with an increased risk of MAU(OR=4.026,95%CI:1.045-15.515;OR=4.043,95%CI:1.252-13.057).Conclusion The 24-hour urinary sodium and sodium-potassium ratio are positively associated with the prevalence of MAU,while 24-hour urinary potassium is not related to the prevalence of MAU.

关 键 词：24 h尿钠 24 h尿钾 钠钾比 微量白蛋白尿 

分 类 号：R195.4[医药卫生—卫生统计学]