类风湿关节炎检查与诊断中RF、抗CCP、AKA单独或联合检验的作用  

The Role of RF,Anti-CCP,AKA Alone or Combined Tests in Rheumatoid Arthritis Examination and Diagnosis

作　　者：汤伟明 徐燕[1] TANG Weiming;XU Yan(Department of Laboratory Medicine,Liyang People's Hospital,Changzhou,Jiangsu 213300)

机构地区：[1]溧阳市人民医院检验科,江苏常州213300

出　　处：《智慧健康》2024年第2期76-79,共4页Smart Healthcare

摘　　要：目的 探究类风湿关节炎检查与诊断中RF(类风湿因子)、抗CCP(抗环瓜氨酸多肽抗体)、AKA(抗角蛋白抗体)单独或联合检验的作用。方法 选取2019年1月—2021年12月本院收治的类风湿关节炎患者47例(试验组)与非类风湿关节炎的自身免疫性疾病患者47例(对照组)作为研究对象,分析单独检验及联合检验的检出率,判断临床诊断价值。结果 试验组RF、抗CCP抗体、AKA阳性率均高于对照组,差异有统计学意义(P<0.05)。单独RF、抗CCP抗体、AKA对比灵敏度无差异(P>0.05);AKA、抗CCP抗体特异度高于RF,差异显著有统计学意义(P<0.05)。RF+抗CCP抗体+AKA诊断效能最高,差异有统计学意义(P<0.05)。结论RF、抗CCP、AKA联合应用于类风湿关节炎诊断效能显著,应用价值高。Objective To investigate the role of RF(Rheumatoid factor),anti-CCP(anticyclic citrulline polypeptide antibody),AKA(anti-keratin antibody) alone or in combination in the examination and diagnosis of rheumatoid arthritis.Methods 47 patients with rheumatoid arthritis(trial group) and 47 patients with autoimmune diseases without rheumatoid arthritis(control group)admitted to our hospital from January 2019 to December 2021 were selected as the study objects,and the detection rate was analyzed to judge the clinical diagnostic value.Results The positive rates of RF,anti-CCP antibody and AKA in experimental group were higher than those in control group,with statistical difference(P<0.05).There was no difference in the sensitivity of RF,anti-CCP antibody and AKA alone(P>0.05).The specificity of AKA and anti-CCP antibody was higher than that of RF,the difference was significant(P<0.05),and the diagnostic efficiency of RF+ anti-CCP antibody+ AKA was the highest,with statistical difference(P<0.05).Conclusion The combined application of RF,anti-CCP and AKA in the diagnosis of rheumatoid arthritis has significant efficacy and high application value.

关 键 词：RF 抗CCP AKA 类风湿关节炎 

分 类 号：R593.22[医药卫生—内科学] R446.6[医药卫生—临床医学]