有机催化吲哚的不对称Friedel-Crafts烷基化反应研究进展  

Research Progress in Asymmetric Friedel-Crafts Alkylation of Indoles Catalyzed by Organic Catalysts

作　　者：曾宣云 Zeng Xuanyun(Lanzhou Jiaotong University,Lanzhou 730070,China)

机构地区：[1]兰州交通大学,甘肃兰州730070

出　　处：《广东化工》2024年第5期52-56,29,共6页Guangdong Chemical Industry

摘　　要：功能化吲哚在许多研究领域有广泛的应用,因此旋光性吲哚衍生物的合成在有机合成中有重要的意义。催化不对称Friedel-Crafts烷基化是研究吲哚区域选择性功能化最直接、最彻底的方法。本文综述了近二十年来有机催化剂催化吲哚的不对称Friedel-Crafts烷基化反应的进展,并对此作出总结与展望。Functionalized indoles are widely used in many research fields,so the synthesis of optically active indole derivatives is of great significance in organic synthesis.Catalytic asymmetric Friedel-Crafts alkylation is the most direct and thorough method to study the regioselective functionalization of indoles.In this paper,the progress of asymmetric Friedel-Crafts alkylation of indoles catalyzed by organic catalysts in recent 20 years is reviewed,and the summary and prospect are made.

关 键 词：不对称催化 有机催化剂 吲哚 Friedel-Crafts烷基化 

分 类 号：O62[理学—有机化学]