甘油三酯-葡萄糖指数与γ-谷氨酰基转移酶在中青年代谢综合征诊断中的临床应用  

Application of triglyceride glucose and gamma-glutamyl transferase in the diagnosis of metabolic syndrome in young and middle-aged people

作　　者：刘柳 孙然 王霞 葛菁 张圣强 Liu Liu;Sun Ran;Wang Xia;Ge Jing;Zhang Shengqiang(Department of Clinical Laboratory,Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China)

机构地区：[1]首都医科大学附属北京世纪坛医院医学检验科,北京100038

出　　处：《中国医刊》2024年第4期381-386,共6页Chinese Journal of Medicine

摘　　要：目的探讨甘油三酯-葡萄糖(TyG)指数与γ-谷氨酰基转移酶(GGT)预测中青年代谢综合征(MS)的临床价值。方法选取2022年12月至2023年9月在首都医科大学附属北京世纪坛医院肥胖与代谢中心住院治疗的151例中青年MS患者作为研究对象(MS组),另选取同期在医院进行健康体检者130例作为对照组,分别测定两组的代谢及炎症指标。MS组根据MS组分数目分为MS3组(101例)、MS4组(32例)及MS5组(18例),比较三组TyG指数、GGT水平。采用Pearson相关检验分析TyG指数、GGT与MS诊断指标的相关性。通过多因素logistic回归分析MS发生的危险因素。使用受试者操作特征(ROC)曲线评估TyG指数、GGT预测MS的价值。结果MS组患者TyG指数、GGT显著高于对照组,MS5组TyG指数、GGT显著高于MS3组和MS4组,差异均有统计学意义(P<0.05)。Pearson相关分析显示,TyG指数、GGT水平与体重指数、舒张压、收缩压、空腹血糖、甘油三酯呈正相关(P<0.05),与高密度脂蛋白胆固醇呈负相关(P<0.05)。Logistic回归分析显示,TyG指数、GGT均为MS的危险因素。ROC曲线分析显示,TyG指数、GGT预测MS的曲线下面积(AUC)分别为0.72(95%CI 0.66~0.781)、0.675(95%CI 0.612~0.739)结论中青年MS患者TyG指数、GGT表达明显增高,二者均与MS的发生密切相关。Objective To explore the diagnostic value of triglyceride glucose(TyG)index and γ-glutamyl transferase(GGT)in metabolic syndrome(MS)of middle-aged and young adults.Method One hundred and fifty-one cases with MS in Beijing Shijitan Hospital from December 2022 to September 2023 were selected as the research objects.At the same time,130 healthy adults were selected as the control group,and the metabolic and inflammatory indicators of the two groups of were measured respectively.According to the number of diagnosed components of MS patients,they were divided into MS3 group(101 cases),MS4 group(32 cases)and MS5 group(18 cases),and TyG index and GGT levels were compared among the three groups.Pearson correlation was used to analyse the correlation between TyG index,GGT,and MS diagnostic indicators.The risk factors of MS were analyzed through multi-factor logistic regression.Receiver operating characteristic(ROC)curve was used to evaluate the value of TyG index and GGT to predict MS.Result The TyG index and GGT of patients in the MS group were significantly higher than that of the control group,and TyG index and GGT were higher in the MS5 group than in the MS3 and MS4 groups.Pearson correlation analysis showed that the TyG index and GGT level were positively correlated with BMI,DBP,SBP,FPG and TG(P<0.05),and negatively correlated with HDL-C(P<0.05).Logistic regression analysis showed that TyG index and GGT were both risk factors for MS.ROC curve analysis showed that the area AUC under the curve of TyG index,and GGT to predict the incidence of MS was 0.720(95%CI 0.660-0.781),0.675(95%CI 0.612-0.739).Conclusion The TyG index and GGT were highly expressed in young and middle-aged MS patients,both of which were closely related to MS.

关 键 词：代谢综合征 甘油三酯-葡萄糖指数 Γ-谷氨酰基转移酶 

分 类 号：R589[医药卫生—内分泌]