丹参调控糖脂代谢作用研究进展  

Research progress in Danshen(Salviae Miltiorrhizae Radix et Rhizoma)in regulation of glucose and lipid metabolism

作　　者：黄傲 方晓洋 何维维 文馨月 成飞 徐琳本[2] 曾宏亮 HUANG Ao;FANG Xiao-yang;HE Wei-wei;WEN Xin-yue;CHENG Fei;XU Linben;ZENG Hong-liang(Hunan Academy of Chinese Medicine,Hunan University of Chinese Medicine,Changsha 410208;Center of Medical Laboratory Animals,Hunan Academy of Chinese Medicine,Changsha 410013;Institute of Chinese Medicine Resources,Hunan Academy of Chinese Medicine,Changsha 410013)

机构地区：[1]湖南中医药大学湖南省中医药研究院,长沙410208 [2]湖南省中医药研究院医学实验动物中心,长沙410013 [3]湖南省中医药研究院中药资源研究所,长沙410013

出　　处：《中南药学》2024年第3期733-741,共9页Central South Pharmacy

基　　金：湖南省自然科学基金面上项目(No.2021JJ30416);湖南省中医药科研计划项目(No.202023);湖南省重点领域研发计划项目(No.2020SK2141);湖南省高新技术产业科技创新引领计划(No.2020SK2051)。

摘　　要：丹参(Salviae Miltiorrhizae Radix et Rhizoma)是唇形科、鼠尾草属多年生直立草本植物,其干燥根和根茎常用于心血管疾病的治疗,为我国传统医学中的常见药材。研究结果表明,丹参提取物及主要活性成分丹酚酸、丹参酮等通过调节炎症、过氧化等多靶点多信号途径改善糖脂代谢。本文梳理了近年来的研究成果,总结丹参及其活性物质调控糖脂代谢的作用与机制研究进展,以期为丹参应用于糖尿病与肥胖等代谢性疾病的防治提供参考。Danshen(Salviae Miltiorrhizae Radix et Rhizoma)is a perennial upright herb belonging to the genus Salvia and Labiatae.Its dry roots and rhizomes are medicinal materials in traditional Chinese medicine,commonly used for cardiovascular diseases.Salviae Miltiorrhizae Radix et Rhizoma extract and its main active components,such as salvianolic acid and tanshinone,could improve the glucose and lipid metabolism by regulating the inflammation,peroxidation related targets and signaling pathways.This paper reviewed the research in recent years,summarized the progress in the effect and mechanism of Salviae Miltiorrhizae Radix et Rhizoma and its active substances in regulating the glucose and lipid metabolism,to provide reference for the application of Salviae Miltiorrhizae Radix et Rhizoma in the treatment of diabetes and obesity.

关 键 词：丹参 糖代谢 脂代谢 信号通路 研究进展 

分 类 号：R285[医药卫生—中药学]