结核丸联合抗结核化疗药物治疗儿童肺结核的临床疗效  

Clinical effect of tuberculosis pills combined with anti-tuberculosis chemotherapy drugs on children with pulmonary tuberculosis

作　　者：陈芳 江杰 危松青 李嘉 周海依 CHEN Fang;JIANG Jie;WEI Song-qing;LI Jia;ZHOU Hai-yi(Department of Student and Child Tuberculosis,Changsha Central Hospital Afflliated to Hengyang Medical School,University of South China,Changsha 410004;Department of Pediatrics,Changsha Central Hospital Afflliated to Hengyang Medical School,University of South China,Changsha 410004)

机构地区：[1]南华大学衡阳医学院附属长沙中心医院学生儿童结核科,长沙410004 [2]南华大学衡阳医学院附属长沙中心医院儿科,长沙410004

出　　处：《中南药学》2024年第3期805-809,共5页Central South Pharmacy

基　　金：湖南省卫生健康委项目(No.D202306016238)。

摘　　要：目的分析结核丸联合标准化抗结核治疗方案治疗儿童初治病原学阳性肺结核患儿的临床疗效及安全性。方法回顾性分析2018年6月至2022年6月就诊的儿童初治病原学阳性肺结核患儿,按是否使用过结核丸,分为结核丸组和对照组,结核丸组给予结核丸加标准化抗结核治疗方案HRZ(E)治疗,对照组仅给予HRZ(E)治疗,比较两组患儿的临床疗效及安全性。结果结核丸组及对照组分别纳入61例和101例患儿,两组患儿治疗前基线资料差异无统计学意义。在临床疗效方面,治疗2个月后,结核丸组痰检阴转率明显高于对照组(P<0.05)。结核丸组影像学病灶显著吸收率明显高于对照组(P<0.05)。在实验室指标改善方面,治疗2个月后结核丸组的血红蛋白、血清前白蛋白较对照组改善更为明显,结核丸组血尿酸升高低于对照组(P<0.05)。在安全性方面,结核丸组的总体药物不良反应发生率与对照组比较,差异无统计学意义,但结核丸组肝功能异常发生率明显低于对照组(P<0.05)。结论结核丸联合标准化抗结核治疗方案可提高儿童初治病原学阳性肺结核患儿的痰检阴转率,促进肺部病灶吸收,改善贫血及营养不良,减少抗结核药物性肝损伤的发生率。Objective To determine the clinical efficacy and safety of tuberculosis pills combined with standard chemotherapy treatment in children with newly diagnosed pathogen positive pulmonary tuberculosis.Methods Children newly diagnosed pathogen positive pulmonary tuberculosis from June 2018 to June 2022 were retrospectively analyzed,and divided into a tuberculosis pill group and a control group based on whether they had used tuberculosis pills.The tuberculosis pill group was given tuberculosis pills plus standard chemotherapy treatment including HRZ(E),while the control group was only given HRZ(E).Results Totally 61 children were included in the tuberculosis pills group and 101 children in the control group.There was no significant difference in the baseline information between the two groups before the treatment.After two months of treatment,the sputum negative conversion rate,and focus absorption effective rate in the tuberculosis pill group were much higher than those in the control group(P<0.05).The hemoglobin and serum pre-albumin in the tuberculosis pill group improved more significantly than those in the control group,but the blood uric acid elevation in the tuberculosis pill group was lower than that in the control group(P<0.05).In terms of safety,the overall incidence of adverse drug reactions in the tuberculosis pills group showed no significant different in the two groups,but the incidence of liver dysfunction in the tuberculosis pill group was much lower than that in the control group(P<0.05).Conclusion Besides standard chemotherapy treatment,tuberculosis pills help increase the rate of negative conversion of sputum bacteria,promote lung lesion absorption,improve anemia and malnutrition,and reduce the incidence of anti-tuberculosis drug-induced liver injury in children with newly diagnosed pathogen positive pulmonary tuberculosis.

关 键 词：结核丸 抗结核化疗药物 肺结核 儿童 

分 类 号：R521[医药卫生—内科学]