蒲公英抗膀胱癌潜在机制的研究进展  

Potential Mechanism of Taraxaci Herba Against Bladder Cancer:A Review

作　　者：左明顺 董志诚 左玉 陈洪川 蔡宏佳 吴丛丛 艾小渝 张能 ZUO Mingshun;DONG Zhicheng;ZUO Yu;CHEN Hongchuan;CAI Hongjia;WU Congcong;AI Xiaoyu;ZHANG Neng(Affiliated Hospital of Zunyi Medical University,Zunyi 563000,China;People's Hospital of Lixia District of Jinan,Jinan 250013,China)

机构地区：[1]遵义医科大学附属医院,贵州遵义563000 [2]济南历下区人民医院,济南250013

出　　处：《中国实验方剂学杂志》2024年第7期290-298,共9页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81860524)。

摘　　要：膀胱癌(BCa)是泌尿系统最常见的恶性肿瘤,其发病率逐年上升。目前对所有可切除的非转移性肌层浸润性膀胱癌患者,强烈建议行根治性膀胱切除术+双侧盆腔淋巴结清扫,但其术后仍面临着复发、转移、死亡的风险。近年来,晚期和转移性BCa患者在新诊断BCa患者中的比例不断升高。虽然目前的治疗模式多样,但由于其有效性低及不良反应较大,往往难以取得显著疗效,导致晚期和转移性BCa患者生存率仍然较低。因此BCa的治疗仍然面临巨大挑战,迫切需要发现一种有效的新型抗肿瘤药物。随着医疗水平的提升,中药药物在BCa患者治疗中显示出极大优势。中药温和,易接受,可通过多途径、多方式、多靶点抑制肿瘤进展,从而发挥抗癌作用。蒲公英是一种药食同源植物,具有抗菌、抗炎、抗氧化、抗肿瘤、保肝利胆、降糖和增强免疫力等多种生物活性,其已在乳腺癌、肝癌、胃癌、舌癌和肺癌等癌症中显示出明确的抗癌作用。通过回顾既往国内外研究,该文对蒲公英提取物通过诱导细胞发生自噬、诱导细胞凋亡、抑制细胞迁移与侵袭、调节细胞的周期和增殖、调节细胞代谢、抑制肿瘤血管生成、联合化疗药物的作用、调控相关信号通路的转导的机制进行总结,系统阐述蒲公英抗BCa的潜在作用机制,以期为BCa的研究和治疗提供一定的理论依据。Bladder cancer(BCa) is the most common malignant tumor of the urinary system,and its incidence is increasing year by year.At present,for all patients with resectable non-metastatic muscle-invasive BCa,radical cystectomy + bilateral pelvic lymph node dissection is strongly recommended,but they still face the risk of recurrence,metastasis and death.In recent years,the proportion of patients with advanced and metastatic BCa is increasing among patients with newly diagnosed BCa.Although current treatment models are diverse,they often struggle to achieve significant efficacy due to their low effectiveness and adverse effects,resulting in low survival rates for patients with advanced and metastatic BCa.Therefore,the treatment of BCa still faces great challenges,and there is an urgent need to discover an effective new antitumor drug.With the improvement of medical standards,traditional Chinese medicine has shown great advantages in the treatment of BCa.Traditional Chinese medicine is mild and easy to accept,and can inhibit tumor progression through a multipathway,multi-way and multi-target manner,so as to exert its anticancer effect.Taraxaci Herba is a medicinal and food homologous plant,which has many biological activities,such as antibacterial,anti-inflammatory,antioxidation,anti-tumor,protecting liver and gallbladder,reducing blood sugar and enhancing immunity,and it has shown a clear anticancer effect in breast cancer,liver cancer,gastric cancer,tongue cancer and lung cancer.By reviewing previous studies worldwide,this article summarizes the mechanism of Taraxaci Herba extract in inducing autophagy and apoptosis,inhibiting cell migration and invasion,regulating cell cycle and proliferation,regulating cell metabolism,inhibiting tumor angiogenesis,combining the effects of chemotherapeutic drugs,and regulating the transduction of related signal pathways.On this basis,this study systematically elaborates on the potential mechanism of Taraxaci Herba against BCa,in order to provide a theoretical basis for the research and

关 键 词：蒲公英 膀胱癌 泌尿系统 抗癌作用 作用机制 

分 类 号：R2-0[医药卫生—中医学] R22R242R2-031R285.5