司美格鲁肽注射液治疗成人2型糖尿病的临床综合评价  

Comprehensive clinical evaluation of semaglutide injection for the treatment of diabetes mellitus type 2 in adults

作　　者：贺兰芝 周鹏翔[2,3] 秦永洁 林春燕 区燕婷[1] 何颖 李桂德 周甘平 HE Lan-zhi;ZHOU Peng-xiang;QIN Yong-jie;LIN Chun-yan;OU Yan-ting;HE Ying;LI Gui-de;ZHOU Gan-ping(Department of Pharmacy,Jiangbin Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China;Department of Pharmacy,Peking University Third Hospital,Beijing 100191,China;Institute for Drug Evaluation,Peking University Health Science Center,Beijing 100191,China;Department of Endocrinology,Jiangbin Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China)

机构地区：[1]广西壮族自治区江滨医院药学部,南宁530021 [2]北京大学第三医院药剂科,北京100191 [3]北京大学医学部药物评价中心,北京100191 [4]广西壮族自治区江滨医院内分泌科,南宁530021

出　　处：《临床药物治疗杂志》2024年第2期31-36,共6页Clinical Medication Journal

基　　金：2022—2023年度广西壮族自治区卫生健康委药品临床综合评价课题(YPPJ003)。

摘　　要：目的 对司美格鲁肽注射液进行临床综合评价,为其临床决策和合理用药提供参考。方法 采用系统性文献综述、问卷调研等方法,对司美格鲁肽注射液的有效性、安全性、经济性、创新性、适宜性和可及性进行定性与定量分析。结果 有效性和安全性方面,司美格鲁肽可显著降低糖化血红蛋白(HbA1c)、空腹血糖和体质量,提高HbA1c的达标率。其总体安全性较好,低血糖风险低,胃肠道不良反应发生风险高于或与对照药物相当。经济性方面,司美格鲁肽比度拉糖肽和洛塞那肽更具有经济学优势。司美格鲁肽被国内外临床指南推荐,具有良好的临床创新性。在适宜性方面,司美格鲁肽具有较好的给药便利性、依从性等。在可及性方面,司美格鲁肽的可负担性较好,但中标区域数和医疗机构的配备率较低,存在短缺情况。结论 司美格鲁肽注射液具有良好的有效性、安全性、经济性、创新性、适宜性和可负担性,可获得性有待进一步改善。Objective Comprehensive clinical evaluation of semaglutide injection was conducted to provide a reference for clinical decision-making and rational use of this drug.Methods A systematic literature review and questionnaire surveys were used,to perform a qualitative and quantitative analysis of the efficacy,safety,economy,innovation,suitability,and accessibility of the drugs.Results In terms of efficacy and safety,semaglutide significantly reduces glycated hemoglobin A1c(HbA1c) levels,fasting blood glucose,and body weight,while also improving the achievement rate of HbA1c targets.The overall safety of semaglutide injection was good,with a low risk of hypoglycemia,although the risk of gastrointestinal adverse reactions was higher or similar to other antidiabetic drugs.In terms of economy,semaglutide injection demonstrates greater economic advantages compared to dulaglutide and loxenatide.With good clinical innovation,semaglutide injection was recommended by clinical guidelines both domestically and internationally.In terms of dosing convenience and compliance,it exhibits good suitability for use.Semaglutide injection exhibits good affordability,but the number of bid-winning areas and the rate of medical institution distribution were relatively low,leading to shortages.Conclusion Semaglutide injection demonstrates good efficacy,safety,economy,innovation,suitability,and affordability.However,its availability needs to be further improved.

关 键 词：司美格鲁肽 2型糖尿病 临床综合评价 胰高血糖素样肽-1受体 

分 类 号：R979.9[医药卫生—药品]