两性霉素B治疗获得性免疫缺陷综合征合并深部真菌感染疗效及安全性的回顾性分析  

A retrospective analysis of the effectiveness and safety of amphotericin B in the treatment of acquired immune deficiency syndrome with deep fungal infection

作　　者：孙娜 刘慧 战寒秋 SUN Na;LIU Hui;ZHAN Han-qiu(Department of Pharmacy,Beijing Ditan Hospital Capital Medical University,Beijing 100015,China)

机构地区：[1]首都医科大学附属北京地坛医院药学部,北京100015

出　　处：《临床药物治疗杂志》2024年第2期80-83,共4页Clinical Medication Journal

摘　　要：目的 回顾性分析两性霉素B治疗AIDS合并深部真菌感染的疗效及安全性。方法 收集2019年1月1日至2023年5月31日在首都医科大学附属北京地坛医院接受两性霉素B治疗的AIDS合并深部真菌感染患者资料,对其用药期间的疗效及安全性指标进行监测。结果 共纳入患者25例。总有效率为84.0%,症状好转率为68.0%,22例发生不良反应,12例发生严重不良反应,不良反应类型以低钾血症、骨髓抑制、肾功能损伤和肝功能异常为主。结论 两性霉素B具有较高的临床疗效,但不良反应发生率高,临床使用时应密切监护。Objective To retrospectively analyze the effectiveness and safety of amphotericin B in AIDS patients with deep fungal infection.Methods A retrospective review was conducted on the medical records of AIDS patients treated with amphotericin B for deep fungal infections at Beijing Ditan Hospital,Capital Medical University,from January 1,2019,to May 31,2023.The effectiveness and safety indicators during the treatment period were monitored and analyzed.Results A total of 25 patients were included.The overall effectiveness rate was 84.0% and the symptom improvement rate was 68.0%;22 cases experienced adverse reactions,and 12 cases experienced serious adverse reactions.The most common types of adverse reactions were hypokalemia,bone marrow suppression,renal impairment,and liver function abnormality.Conclusion Amphotericin B demonstrates great clinical efficacy in treating deep fungal infections in AIDS patients.However,due to its high rate of adverse reactions,close monitoring is required during clinical use.

关 键 词：两性霉素B 获得性免疫缺陷综合征 真菌感染 疗效 不良反应 

分 类 号：R978.5[医药卫生—药品]