芪术石斛养胃方对慢性萎缩性胃炎患者中医证候和胃肠功能的影响  

Effect of Qizhu Shihu Yangwei Formula on traditional Chinese medicine symptoms and gastrointestinal function in patients with chronic atrophic gastritis

作　　者：柳鹏程 李文龙 蔡楚泉 石晓玲 雷格 LIU Pengcheng;LI Wenlong;CAI Chuquan;SHI Xiaoling;LEI Ge(Hunan University of Chinese Medicine,Hunan,Changsha 410208,China;Department of Spleen and Stomach,Changsha Hospital of Traditional Chinese Medicine(Changsha Eighth Hospital),Hunan,Changsha 410100,China)

机构地区：[1]湖南中医药大学,湖南长沙410208 [2]长沙市中医医院(长沙市第八医院)脾胃科,湖南长沙410100

出　　处：《中国医药科学》2024年第6期9-12,16,共5页China Medicine And Pharmacy

基　　金：湖南省长沙市科技计划项目(kq2202060)。

摘　　要：目的探究芪术石斛养胃方对慢性萎缩性胃炎患者中医证候和胃肠功能的影响。方法选取2021年11月至2022年12月在长沙市中医医院收治的100例慢性萎缩性胃炎患者,按照随机数表法将其分为观察组与对照组,每组各50例。对照组采用胃复春片,观察组采用胃复春片+芪术石斛养胃方。比较两组临床疗效、中医证候积分、胃功能、应激反应与炎症因子水平以及不良反应。结果观察组临床有效率为94.00%,高于对照组的68.00%(P<0.05)。治疗前,两组胃脘隐痛、食欲不振、反酸烧心、身倦乏力以及贫血积分比较,差异无统计学意义(P>0.05);治疗后,两组胃脘隐痛、食欲不振、反酸烧心、身倦乏力以及贫血积分均降低,且观察组低于对照组(P<0.05)。治疗前,两组胃动素(MTL)、胃泌素(GAS)比较,差异无统计学意义(P>0.05);治疗后,两组MTL均降低,且观察组低于对照组,GAS均升高,且观察组高于对照组(P<0.05)。治疗前,两组超氧化物歧化酶(SOD)、一氧化氮(NO)、C反应蛋白(CRP)及肿瘤坏死因子-α(TNF-α)比较,差异无统计学意义(P>0.05);治疗后,两组SOD、NO升高,且观察组高于对照组,CRP、TNF-α降低,且观察组低于对照组(P<0.05)。两组均无明显不良反应。结论慢性萎缩性胃炎患者采用芪术石斛养胃方联合胃复春片治疗,能有效提高治疗效果,改善患者胃功能,降低应激反应和炎症因子水平,安全性高。Objective To explore the effects of Qizhu Shihu Yangwei Formula on traditional Chinese medicine(TCM)syndromes and gastrointestinal function in patients with chronic atrophic gastritis.Methods A total of 100 patients with chronic atrophic gastritis treated at Changsha Hospital of Traditional Chinese Medicine from November 2021 to December 2022 were selected.They were randomly divided into an observation group and a control group,with 50 patients in each group.The control group was treated with Weifuquan Tablets,while the observation group received Weifuquan Tablets combined with Qizhu Shihu Yangwei Formula.The clinical efficacy,TCM syndrome scores,gastric function,stress response,levels of inflammatory factors,and adverse reactions of two groups were compared.Results The clinical treatment rate in the observation group was 94.00%,significantly higher than 68.00% in the control group(P<0.05).Before treatment,there were no significant differences between the two groups in terms of epigastric pain,anorexia,acid regurgitation,fatigue,and anemia(P>0.05).After treatment,these symptoms were reduced in both groups,and the observation group was lower than the control group(P<0.05).Before treatment,there was no statistically significant difference in the levels of motilin(MTL)and gastrin(GAS)between the two groups(P>0.05).After treatment,MTL decreased in both groups,and the observation group was lower than the control group,GAS increased in both groups,and the observation group was higher than the control group(P<0.05).Before treatment,there were no significant differences in superoxide dismutase(SOD),nitric oxide(NO),C-reactive protein(CRP),and tumor necrosis factor-α(TNF-α)levels between the two groups(P>0.05).After treatment,SOD and NO levels increased,while CRP and TNF-α levels decreased in both groups,and the observation group was lower than the control group(P<0.05).No adverse reactions were observed in either group.Conclusion The combination of Qizhu Shihu Yangwei Formula with Weifuquan Tablets in the treatment of

关 键 词：芪术石斛养胃方 慢性萎缩性胃炎 中医证候 胃肠功能 

分 类 号：R259[医药卫生—中西医结合]