炎性因子在妊娠期糖尿病发病中的作用研究进展  

Research progress on the role of inflammatory factors in the pathogenesis of gestational diabetes mellitus

作　　者：华景荷 葛莉[1] 林钰铮 张辰钧 张梦婷 于红虹[1] HUA Jinghe;GE Li;LIN Yuzheng;ZHANG Chenjun;ZHANG Mengting;YU Honghong(School of Nursing,Fujian University of Traditional Chinese Medicine,Fujian,Fuzhou 350122,China)

机构地区：[1]福建中医药大学护理学院,福建福州350122

出　　处：《中国医药科学》2024年第6期43-46,63,共5页China Medicine And Pharmacy

基　　金：福建省自然科学基金计划项目高校联合资助面上项目(2021J01945)。

摘　　要：妊娠期糖尿病(GDM)发病率呈逐年上升趋势,该病会增加母婴心血管并发症发生风险,威胁母婴安全。GDM的发病机制尚未完全阐明,随着研究的进展,免疫炎性失调在GDM发病机制中的作用日益受到重视。GDM的发病与患者体内的慢性炎症状态有关,众多炎性因子不仅参与胰岛素抵抗(IR)致使GDM的发生,也通过损伤胰岛β细胞促进GDM的发展。本文综述与GDM发病相关的主要促炎因子白细胞介素(IL)-2、IL-6、肿瘤坏死因子-α(TNF-α)、IL-1β、干扰素-γ(IFN-γ)、C反应蛋白(CRP)、IL-17的作用机制及其与GDM发病的相关性研究,以期为GDM的防治提供参考依据。Objective The incidence rate of gestational diabetes mellitus(GDM)is increasing year by year,which will increase the risk of cardiovascular complications in mothers and infants and threaten the safety of mothers and infants.The pathogenesis of GDM has not been fully elucidated,and with the progress of research,the role of immune-inflammatory disorders in the pathogenesis of GDM is increasingly being valued.The pathogenesis of GDM is related to the chronic inflammatory state in the patient’s body.Most inflammatory factors not only participate in insulin resistance(IR),leading to GDM,but also damage the pancreatic β cells,promoting the development of GDM.This article reviews the mechanism of action of the main pro-inflammatory factors related to the pathogenesis of GDM,including interleukin(IL)-2,IL-6,tumor necrosis factor-α(TNF-α),IL-1β,interferon-γ(IFN-γ),C-reactive protein(CRP)and IL-17,and studies on their correlation with the pathogenesis of GDM,so as to provide a reference for the preve ntion and treatment of GDM.

关 键 词：妊娠期糖尿病 炎性因子 胰岛素抵抗 胰岛Β细胞功能障碍 发病机制 

分 类 号：R714.256[医药卫生—妇产科学]