SIRT1在儿童呼吸系统疾病中的研究进展  

Research progress of SIRT1 in children with respiratory disease

作　　者：赵晨羽 马莲美[1] ZHAO Chenyu;MA Lianmei(Department of Pediatrics,Binzhou Medical University Hospital,Shandong,Binzhou 256600,China)

机构地区：[1]滨州医学院附属医院儿科,山东滨州256600

出　　处：《中国医药科学》2024年第6期51-54,共4页China Medicine And Pharmacy

摘　　要：沉默信息调节因子2相关酶1(SIRT1)是一种高度保守的烟酰胺腺嘌呤二核苷酸(NAD+)依赖的Ⅲ类组蛋白去乙酰化酶,通过对组蛋白和非组蛋白在内的靶蛋白的去乙酰化作用发挥生理学效应。在呼吸系统中,SIRT1参与调节炎症反应、氧化应激、细胞凋亡和自噬等过程。SIRT1的活性异常与肺炎、哮喘、急性肺损伤、慢性阻塞性肺疾病、特发性肺纤维化、肺癌等呼吸系统疾病的发生与发展密切相关。近年来,随着对SIRT1与呼吸系统疾病的关系以及调控SIRT1药物的深入研究,为呼吸系统疾病的治疗提供了新的思路。本文就SIRT1在儿童呼吸系统疾病发病机制中的作用及其最新研究进展做一综述,以更好地将SIRT1作为一个靶点服务于儿童呼吸系统疾病。Silent information regulator 2-related enzyme 1(SIRT1)is a highly conserved nicotinamide adenine dinucleotide(NAD+)dependent class Ⅲ histone deacetylase,which exerts physiological effects through deacetylation of target proteins,including histones and nonhistones.In the respiratory system,SIRT1 is involved in regulating processes such as inflammatory response,oxidative stress,cell apoptosis,and autophagy.The abnormal activity of SIRT1 is closely related to the occurrence and development of respiratory diseases such as pneumonia,asthma,acute lung injury,chronic obstructive pulmonary disease,idiopathic pulmonary fibrosis,lung cancer,etc.In recent years,with the in-depth study of the relationship between SIRT1 and respiratory diseases and the regulation of SIRT1 drugs,new ideas have been provided for the treatment of respiratory diseases.This paper reviews the role of SIRT1 in the pathogenesis of children’s respiratory disease and its latest research progress,to better serve children’s respiratory disease as a target.

关 键 词：沉默信息调节因子2相关酶1 儿童 呼吸系统疾病 机制 

分 类 号：R56[医药卫生—呼吸系统]