人参归脾丸中5种重金属元素残留测定分析  

Detection of five heavy metal impurities in Renshenguipi pills

作　　者：王丹彧 张亦萌 程焱 李正刚 李本淳 马彧[1] WANG Dan-yu;ZHANG Yi-meng;CHEN Yan;LI Zheng-gang;LI Ben-chun;MA Yu(Department of Traditional Chinese Medicine,Siping Institute for Food and Drug Control,Siping,Jilin 136000,China)

机构地区：[1]四平市食品药品检验所中药室,吉林四平136000

出　　处：《中国卫生工程学》2024年第1期23-26,共4页Chinese Journal of Public Health Engineering

基　　金：吉林省科技厅项目重点研发医药健康领域(20210204151YY)。

摘　　要：目的 建立人参归脾丸中(Pb)、砷(As)、铜(Cu)、镉(Cd)、汞(Hg)5种重金属元素的残留检测方法。方法 采集人参归脾丸大蜜丸和小蜜丸为样品,样品经微波消解后,以锗(72Ge)、铟(115In)、铋(209Bi)混合溶液作为内标,采用电感耦合等离子体质谱(ICP-MS)进行5种重金属元素的残留量测定。结果 Pb、As、Cu、Cd、Hg 5种重金属元素的线性关系良好(r≥0.999 6),回收率在93.86%~103.44%范围内RSD≤2.2%,方法的检出限在0.001 0~0.092 0 mg/kg范围内。结论 该检测方法准确,灵敏度高。人参归脾丸中5种重金属元素均得到较好控制。Objective To establish a method for the detection of five heavy metal impurities including lead(Pb),arsenic(As),copper(Cu),cadmium(Cd)and mercury(Hg)in Renshenguipi pills.Methods The samples of Renshenguipi pills were digested by microwave,and the mixed solutions of 72 Ge,115 In and 209 Bi were used as internal standards.Inductively coupled plasma mass spectrometry(ICP-MS)was used to determine the impurities of Pb,As,Cu,Cd and Hg.Results The five heavy metal impurities showed good linearity within the selected concentration ranges(r≥0.9996)with the recovery ratio ranging from 93.86% to 103.44%(RSD≤2.2%).The detection limit of the method ranged from 0.0010-0.0920 mg/kg.Conclusion The method is accurate and sensitive,and its application contributes to the good control of the five heavy metal impurities in Renshenguipi pills.

关 键 词：人参归脾丸 微波消解 电感耦合等离子体质谱 重金属元素 

分 类 号：R284[医药卫生—中药学]