2005-2020年北京市丰台区开始接受抗病毒治疗HIV/AIDS患者生存状况分析  

Survival of HIV/AIDS patients with antiretroviral therapy initiated in 2005-2020:an analysis based on data from Fengtai District of Beijing

作　　者：李彦奇[1] 尚翠 司芬芬 肖丹朝 任航 史文雅[1] 许京春[1] 王欣心[1] LI Yan-qi;SHANG Cui;SI Fen-fen;XIAO Dan-zhao;REN Hang;SHI Wen-ya;XU Jing-chun;WANG Xin-xin(Department of AIDS/STD Control and Prevention,Fengtai District Center for Disease Control and Prevention,Beijing 100071,China)

机构地区：[1]北京市丰台区疾病预防控制中心性病艾滋病防制科,北京100071

出　　处：《中国卫生工程学》2024年第1期38-41,共4页Chinese Journal of Public Health Engineering

基　　金：丰台区卫生健康系统“丰泽计划”支持项目(2021-40558)。

摘　　要：目的 分析2005-2020年北京市丰台区接受艾滋病抗逆转录病毒治疗(ART)病例的生存状况及影响因素。方法 收集中国艾滋病综合防治信息系统中丰台区2005-2020年参加艾滋病抗病毒治疗病例数据资料,进行回顾性队列研究,采用寿命表法计算生存率,利用Cox比例风险回归模型分析生存时间的影响因素。结果 共纳入研究对象3 417例,因艾滋病引起相关死亡40例,接受艾滋病抗病毒治疗后第1、3、5、10、15年累计生存率分别为99.24%、99.02%、98.83%、97.05%、97.05%。多因素Cox模型分析结果显示,与15~29岁年龄组、CD4+T淋巴细胞计数≥500个/μl相比,≥50岁(HR=3.46,95%CI:1.00~11.90)、基线CD4+T淋巴细胞计数<200个/μl(HR=12.71,95%CI:1.70~95.25)是参加ART病例死亡的独立危险因素。结论 2005—2020年北京市丰台区参加ART的艾滋病病例生存率较高。但仍需继续加强早发现、早治疗工作,重点关注高年龄段病例,加强治疗效果的相关监测,进一步降低艾滋病相关死亡率。Objective To study the status and associated factors of survival in patients with antiretroviral therapy(ART)initiated in 2005-2020 for human immunodeficiency virus/acquired immunodeficiency syndrome(HIV/AIDS)in Fengtai District of Beijing.Methods A retrospective cohort study was conducted on the follow-up data of patients with ART initia⁃ted from 2005 to 2020 in Fengtai District collected from the National HIV/AIDS Comprehensive Control and Prevention In⁃formation System.The life table method was used to calculate the survival rate.Cox proportional hazards regression model was employed to explore associated factors of survival time.Results A total number of 3417 cases were enrolled.In total,there was 40 HIV/AIDS-related deaths.The cumulative survival rate of patients at 1,3,5,10,and 15 years after ART was 99.24%,99.02%,98.83%,97.05%,and 97.05%,respectively.Multivariate analysis using Cox proportional hazards model revealed that the risk of death was higher in patients aged≥50 years than that in those aged 15-29 years(HR=3.46,95%CI:1.00-11.90),and was higher in patients with baseline CD4+lymphocyte count<200 cells/μl than in those with baseline CD4+lymphocyte count≥500 cells/μl(HR=12.71,95%CI:1.70-95.25).Conclusion The survival rate is relatively high in the study population.To further reduce HIV/AIDS related mortality,early detection and treatment,and monitoring of treatment effect should be continuously strengthened,and high-level attention should be paid to patients of ol⁃der age.

关 键 词：艾滋病 抗病毒治疗 生存分析 影响因素 

分 类 号：R512.91[医药卫生—内科学]