肾脏3.0 T多频磁共振弹性成像:解剖区域、生理因素与正常肾脏硬度的关系  

3.0 T multifrequency magnetic resonance elastography of the kidney:Regional variation and physiological effects on renal stiffness

作　　者：梁秋梅 戚瑞瑞 罗培茵 孟凡琦 盘中贤 陈秋怡 李峻枫 潘劲统 陈玥瑶 LIANG Qiumei;QI Ruirui;LUO Peiyin;MENG Fanqi;PAN Zhongxian;CHEN Qiuyi;LI Junfeng;PAN Jingtong;CHEN Yueyao(Department of Radiology,the fourth Clinical Medical College of Guangzhou University of Chinese Medicine,Shenzhen 518033,China)

机构地区：[1]广州中医药大学第四临床医学院放射影像科,深圳518033

出　　处：《磁共振成像》2024年第3期137-142,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：深圳市科技计划项目(编号:JCYJ20230807094602006)。

摘　　要：目的 应用多频MR弹性成像探讨解剖区域(左肾和右肾,全肾、外皮质、内皮质和髓质)和生理因素(年龄、性别、身体质量指数、饮水情况)与正常肾脏硬度的关系。材料与方法 2023年3月至2023年12月在深圳市中医院招募97名健康志愿者,入组92名受试者,应用3.0 T MR进行多频弹性成像,测量左右侧全肾、外皮质、内皮质及髓质的硬度,比较左右侧不同解剖区域硬度差异,分析年龄、身体质量指数与肾脏硬度的相关性及男女性之间、不同年龄组之间肾脏硬度的差异,最后比较其中18名健康志愿者饮水前后肾脏硬度的变化。结果 左右侧全肾、外皮质、内皮质和髓质的硬度差异无统计学意义(P≥0.05),而肾脏内部不同解剖区域的硬度差异具有统计学意义,其中内皮质最硬[(3.01±0.22)m/s],其次是外皮质[(2.69±0.20)m/s]和全肾[(2.55±0.17)m/s],最后是髓质[(2.16±0.15)m/s]。全肾(r=-0.301,P=0.004)及内皮质(r=-0.330,P=0.001)硬度随年龄增长而轻度降低,并且在三个年龄组之间差异具有统计学意义(P<0.05)。男性肾脏内部不同解剖区域硬度均稍高于女性(P<0.05)。男性和女性饮水后肾脏内部不同解剖区域硬度均高于饮水前(P<0.05),其中外皮质及内皮质增加较明显。结论肾脏硬度存在解剖区域性差异,并且与年龄、性别和饮水情况存在关系。Objective:Multifrequency magnetic resonance elastography was used to investigate the relationships of different anatomical regions of the kidney(left and right kidneys,whole kidney,outer cortex,inner cortex,and medulla)and various physiological factors(age,sex,body mass index,and water intake)on renal stiffness.Materials and Methods:Ninety-two healthy volunteers were recruited from Shenzhen Traditional Chinese Medicine Hospital during the period from March 2023 to December 2023.Multifrequency elastography was employed using a 3.0 T MR to assess the stiffness of renal different anatomical regions,including the whole kidney,outer cortex,inner cortex,and medulla.The aim was to conduct a bilateral comparison of differences between these regions,perform an analysis on the correlation among age,body mass index and kidney stiffness,as well as investigate gender and age disparities in kidney stiffness.Finally,the changes in kidney stiffness before and after drinking water were compared in 18 of the volunteers.Results:There was no difference in the stiffness of the whole kidney,outer cortex,inner cortex and medulla bilaterally(P≥0.05).However,the stiffness of different anatomical regions of the kidney exhibited statistically significant differences,with the inner cortex demonstrating the highest stiffness[(3.01±0.22)m/s],followed by the outer cortex[(2.69±0.20)m/s]and the entire kidney[(2.55±0.17)m/s],while the medulla displayed a slightly lower stiffness[(2.16±0.15)m/s].The stiffness of the whole kidney(r=-0.301,P=0.004)and the inner cortex(r=-0.330,P=0.001)exhibited a slightly decrease with age,as well as differed among the three age groups(P<0.05).The stiffness of different anatomical regions within the kidney was higher in males than in females(P<0.05).The stiffness of different anatomical regions of kidney was higher after drinking water than before in males and females(P<0.05),with particularly notable increases observed in both the outer cortex and inner cortex.Conclusions:The stiffness of the kidney exhibits

关 键 词：肾脏 磁共振成像 多频弹性成像 硬度 剪切波速度 解剖区域 

分 类 号：R445.2[医药卫生—影像医学与核医学] R692[医药卫生—诊断学]