多模态磁共振成像技术在深部脑刺激治疗帕金森病中的研究进展  

Research progress of multimodal MRI in deep brain stimulation therapy for Parkinson's disease

作　　者：刘苗苗 刘泉源[2] 任庆发 徐东昊 李祥林[1] LIU Miaomiao;LIU Quanyuan;REN Qingfa;XU Donghao;LI Xianglin(School of Medical Imaging,Binzhou Medical University,Yantai 264003,China;Department of Radiology,Binzhou Medical University Hospital,Binzhou 256600,China)

机构地区：[1]滨州医学院医学影像学院,烟台264003 [2]滨州医学院附属医院放射科,滨州256600

出　　处：《磁共振成像》2024年第3期200-205,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：山东省重点研发计划(编号:2018YFJH0501)。

摘　　要：帕金森病(Parkinson’s disease,PD)是全球中老年常见的第二大神经退行性疾病,以静止性震颤、肌肉强直、动作迟缓和姿势平衡障碍为显著特征,其患病率预计将在未来三十年内增加一倍。随着药物治疗的弊端逐渐显现,深部脑刺激(deep brain stimulation,DBS)作为一种新型辅助疗法受到广泛关注。MRI可在活体状态下无创地提供脑组织的结构、功能和代谢等信息,对评估DBS治疗PD后的效果及指导治疗具有较大的临床意义。因此,本文就结构MRI(structural MRI,sMRI)、扩散张量成像(diffusion tensor imaging,DTI)、血氧水平依赖功能MRI(blood oxygenation level dependent-functional MRI,BOLD-fMRI)、磁敏感加权成像(susceptibility-weighted imaging,SWI)、定量磁化率成像(quantitative susceptibility mapping,QSM)、磁共振波谱(magnetic resonance spectroscopy,MRS)等多模态MRI技术在DBS治疗PD中的研究进展予以综述,旨在协助临床选择高效、安全的治疗方法,正确评估治疗效果。Parkinson's disease(PD),which is characterized by resting tremor,muscular tonus,bradykinesia,and postural balance abnormalities,is the second most prevalent neurodegenerative disease in middle-aged and older persons worldwide.Its incidence is expected to increase to double in the following three decades.As the negative effects of medicines become increasingly evident,deep brain stimulation(DBS)has gained popularity as a novel type of adjuvant therapy.Magnetic resonance imaging(MRI)can non-invasively provide information on the structure,function,and metabolism of brain tissues in vivo,which is of greater clinical significance for assessing the effects of DBS after treatment of PD and guiding therapy.Therefore,this article provides a review of the research progress of multimodal MRI,including structural magnetic resonance imaging(sMRI),diffusion tensor imaging(DTI),blood oxygenation level dependent-functional magnetic resonance imaging(BOLD-fMRI),susceptibility-weighted imaging(SWI),quantitative magnetic susceptibility mapping(QSM),and magnetic resonance spectroscopy(MRS)in the treatment of PD with DBS,with the aim of assisting the clinic in choosing efficient and safe treatment methods and correctly evaluating the therapeutic effects.

关 键 词：帕金森病 磁共振成像 深部脑刺激 脑结构 脑功能 

分 类 号：R445.2[医药卫生—影像医学与核医学] R742.5[医药卫生—诊断学]