血脂联合白细胞衍生性指标在冠心病患者动脉狭窄及疗效评估中的应用价值  

Application Value of Blood Lipids Combined with Leukocyte-derived Indicators on Arterial Stenosis and Efficacy Evaluation in Patients with Coronary Heart Disease

作　　者：刘书荣 姚利飞 王晓斌 邹富梅 LIU Shu-rong;YAO Li-fei;WANG Xiao-bin;ZOU Fu-mei(Department of Clinical Laboratory,Jizhou District Center for Disease Control and Prevention,Ji'an,Jiangxi,343000,China;Department of Clinical Laboratory,Shanghai Dongfang Hospital Ji'an Hospital,Ji'an,Jiangxi,343006,China;Department of Clinical Laboratory,Ji'an Center for Disease Control and Prevention,Ji'an,Jiangxi,343000,China;Department of Internal Medicine,Jizhou District Center for Disease Control and Prevention,Ji'an,Jiangxi,343000,China)

机构地区：[1]吉安市吉州区疾控中心检验科,江西吉安343000 [2]上海市东方医院吉安医院检验科,江西吉安343006 [3]吉安市疾控中心检验科,江西吉安343000 [4]吉安市吉州区疾控中心内科,江西吉安343000

出　　处：《中国血液流变学杂志》2023年第4期592-596,共5页Chinese Journal of Hemorheology

摘　　要：目的分析血脂联合白细胞衍生性指标在冠心病患者动脉狭窄及疗效评估中的应用价值。方法纳入2019年1月—2023年6月收治的66例冠心病患者,进行回顾性分析,根据其冠状动脉狭窄程度分组并比较其血脂水平[甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]和白细胞衍生性指标水平[中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)],使用受试者工作曲线(ROC)分析血脂联合白细胞衍生性指标评估冠心病患者动脉狭窄程度的价值。治疗后,将术后9个月内发生支架内再狭窄(ISR)或主要心血管不良事件(MACE)的患者纳入观察组,将未发生ISR或MACE的患者纳入对照组,比较两组患者血脂水平和白细胞衍生性指标水平,并使用ROC曲线分析血脂联合白细胞衍生性指标预测冠心病患者疗效的价值。结果相较于轻度狭窄组,中重度狭窄组患者TG、LDL-C、NLR、PLR水平更高,HDL-C水平更低(P<0.05)。ROC曲线中,血脂联合白细胞衍生性指标评估冠心病患者冠状动脉狭窄情况的曲线下面积(AUC)为0.967,敏感度为89.19%,特异度为93.10%。相较于对照组,观察组患者TG、LDL-C、NLR、PLR水平更高,HDL-C水平更低(P<0.05)。ROC曲线中,血脂联合白细胞衍生性指标预测冠心病患者疗效的AUC为0.930,敏感度为84.62%,特异度为86.79%。结论血脂、白细胞衍生性指标与冠心病患者冠状动脉狭窄程度和其治疗疗效密切相关,临床诊治冠心病患者时,需密切关注其血脂及白细胞衍生性指标水平。Objective To analyze the application value of blood lipids combined with leukocyte-derived indicators on arterial stenosis and efficacy evaluation in patients with coronary heart disease.Methods 66 patients with coronary heart disease from January 2019 to June 2023 were included for retrospective analysis and were grouped by means of the degree of coronary artery stenosis.The levels of blood lipids[triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)]and leukocyte-derived indicators[neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR)]were compared between both groups of patients.Receiver operating characteristic(ROC)curve was used to analyze the value of blood lipids combined with leukocyte-derived indicators on evaluating the degree of arterial stenosis.After treatment,patients with in-stent restenosis(ISR)or major adverse cardiovascular events(MACE)within 9 months after surgery were included in observation group,and patients without ISR or MACE were enrolled as control group,and the levels of blood lipids and leukocyte-derived indicators were compared.ROC curve was applied to analyze the value of blood lipids combined with leukocyte-derived indicators on predicting the efficacy.Results Compared with mild stenosis group,the levels of TG,LDL-C,NLR,and PLR in moderate-to-severe stenosis group were higher while the level of HDL-C was lower(P<0.05).In the ROC curve,the area under the curve(AUC),sensitivity and specificity of blood lipids combined with leukocyte-derived indicators in evaluating coronary artery stenosis in patients with coronary heart disease were 0.967,89.19%and 93.10%.The levels of TG,LDL-C,NLR and PLR were higher while the level of HDL-C was lower in observation group compared to control group(P<0.05).In the ROC curve,the AUC,sensitivity and specificity of blood lipids combined with leukocyte-derived indicators were 0.930,84.62%and 86.79%in predicting the efficacy in patients with coronary heart disease.Conclusion Blood lipids and

关 键 词：血脂 白细胞衍生性指标 冠心病 冠状动脉狭窄程度 

分 类 号：R446.11[医药卫生—诊断学] R541.4[医药卫生—临床医学]