线粒体动力相关蛋白1在炎症性肺实质疾病中的作用机制及研究进展  

Research advances on the mechanism of mitochondrial dynamin‑related protein 1 in inflammatory lung parenchymal diseases

作　　者：赵亮 邱蕾 谷长平 张艺 颜杰 闫秀青 王月兰 Zhao Liang;Qiu Lei;Gu Changping;Zhang Yi;Yan Jie;Yan Xiuqing;Wang Yuelan(Department of Anesthesiology,Shandong Provincial Hospital,Shandong University,Jinan 250021,China;Department of Anesthesiology,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,China;School of Anesthesiology,Weifang Medical University,Weifang 261053,China)

机构地区：[1]山东大学附属省立医院麻醉科,济南250021 [2]山东第一医科大学附属省立医院麻醉科,济南250021 [3]潍坊医学院麻醉学院,潍坊261053

出　　处：《国际麻醉学与复苏杂志》2024年第2期190-195,共6页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金(82070078);山东省自然科学基金重点项目(ZR2020KH009);山东省泰山学者科研项目(ts20190981,tsqn201812144)。

摘　　要：线粒体动力相关蛋白1(Drp1)作为介导线粒体分裂的主要蛋白,对维持线粒体的形态、功能和完整性至关重要,并参与细胞的生理活动及疾病的发生、发展进程,尤其在炎症性肺实质疾病的能量代谢中发挥关键调节作用。文章探讨了Drp1的结构与功能,并对其在急性呼吸窘迫综合征、肺动脉高压、哮喘、慢性阻塞性肺疾病中的作用机制进行综述,为炎症性肺实质疾病的防治提供理论依据。As the main protein mediating mitochondrial division,mitochondrial dynamin‑related protein 1(Drp1)is crucial for maintaining the morphology,function,and integrity of mitochondria.It is involved in the physiological activities of cells and the occurrence and development of diseases.In particular,it plays a key role in energy metabolism in inflammatory lung parenchymal diseases.This review discussed the structure and function of Drp1 and reviewed its mechanism in acute respiratory distress syndrome,pulmonary hypertension,asthma,and chronic obstructive pulmonary disease,providing a theoretical basis for the prevention and treatment of inflammatory pulmonary parenchymal diseases.

关 键 词：炎症 肺实质 动力相关蛋白1 线粒体分裂 

分 类 号：R563[医药卫生—呼吸系统]