中年人群高血压与期望寿命关系的前瞻性研究  

The relationship between hypertension and life expectancy in middle aged population:a prospective study

作　　者：袁坤 黄宜林 张林峰[1] 田野[1] 李莹[1] 赵连成[1] YUAN Kun;HUANG Yilin;ZAHNG Linfeng;TIAN Ye;LI Ying;ZHAO Liancheng(Division of Prevention and Community Health,Fuwai Hospital and National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100032,China)

机构地区：[1]中国医学科学院北京协和医学院国家心血管病中心阜外医院社区防治部,北京100032

出　　处：《中华高血压杂志（中英文）》2024年第2期140-146,共7页Chinese Journal of Hypertension

基　　金：国家自然科学基金(81973117)。

摘　　要：目的 基于前瞻性队列探讨高血压对我国中年人群期望寿命的影响。方法 1982—1985年在全国10组35~59岁人群中进行心血管疾病危险因素调查并对死亡结局进行随访。根据基线血压水平将研究对象分为正常血压组、正常高值组和高血压组,采用生存曲线下面积法计算不同血压水平的期望寿命,并进行组间比较。结果 纳入分析的研究对象共24 096人,其中男性12 161人,女性11 935人,平均随访(19.7±4.1)年。多因素分析显示:与正常血压组相比,高血压组人群期望寿命减少7.75(7.64~7.84)年,男性减少6.58(6.45~6.72)年,女性减少8.36(8.26~8.47)年,城市人群减少6.60(6.53~6.68)年,农村人群减少8.72(8.60~8.86)年;与正常血压组相比,正常高值血压人群期望寿命减少2.38(2.27~2.48)年,男性减少1.64(1.52~1.77)年,女性减少2.60(2.51~2.68)年,城市人群减少1.79(1.72~1.86)年,农村人群减少2.45(2.35~2.57)年。结论 无论是高血压还是正常高值血压,均会减少我国中年人群期望寿命。Objective To explore the impact of hypertension on life expectancy in the middle aged Chinese population based on a prospective cohort study.Methods From 1982 to 1985,a cardiovascular risk factor survey was conducted on 10 groups of subjects aged 35 to 59 across China and the death outcomes were followed up.According to the baseline blood pressure level,the subjects were divided into normal blood pressure group,high-normal blood pressure group and hypertension group.The average life expectancy of the subjects with different blood pressure levels was calculated using the area under survival curve method and was compared among groups.Results A total of 24 096 subjects were included in the analysis,including 12 161 males and 11 935 females,with an average follow-up of(19.7±4.1) years.Multivariate analysis showed that compared with subjects in the normal blood pressure group,the life expectancy of the subjects in the hypertension group was reduced.The reduction value was 7.75(7.64-7.84) years in the total population,6.58(6.45-6.72) years in men,8.36(8.26-8.47) years in women,6.60(6.53-6.68) years in urban areas,8.72(8.60-8.86) years in rural areas,respectively.Compared with subjects in the normal blood pressure group,the life expectancy of subjects in the high-normal blood pressure group was reduced,too.The reduction value was 2.38(2.27-2.48) years in the total population,1.64(1.52-1.77) years in men,2.60(2.51-2.68) years in women,1.79(1.72-1.86) years in urban areas,2.45(2.35-2.57) years in rural areas.Conclusion Both hypertension and high-normal blood pressure can reduce the life expectancy of middle aged people in China.

关 键 词：高血压 正常高值 期望寿命 生存曲线下面积 中年 死亡 

分 类 号：R544.1[医药卫生—心血管疾病]