Introducer法经皮内镜下胃造瘘术对食管癌伴吞咽困难患者的效果  

Effects of Introducer Percutaneous Endoscopic Gastrostomy on Nutritional indices,Inflammatory Factor Levels and Pathway Infection in Esophageal Cancer Patients with Dysphagia

作　　者：张丽娟[1] 王改琳 朱芬英 ZHANG Lijuan;WANG Gailin;ZHU Fenying(Department of Minimally Invasive Oncology,the First Affiliated Hospital,School of Clinical Medicine of Henan University of Science and Technology,Luoyang,China,471000;Department of Neurology,the Second Affiliated Hospital of Henan University of Science and Technology,Luoyang,China,471000)

机构地区：[1]河南科技大学临床医学院,河南科技大学第一附属医院肿瘤微创科,洛阳471000 [2]河南科技大学第二附属医院神经内科,洛阳471000

出　　处：《食管疾病》2024年第1期39-43,共5页Journal of Esophageal Diseases

摘　　要：目的探讨Introducer法经皮内镜下胃造瘘术治疗食管癌伴吞咽困难患者的效果。方法选取河南科技大学第一附属医院微创肿瘤科2020年3月至2022年9月收治的96例食管癌伴吞咽困难患者作为研究对象,根据手术方式将患者分为Pull法组和Introducer法组各48例,分别用Pull法或Introducer法行经皮内镜下胃造瘘术建立肠内营养通路,对比两组患者造瘘管更换率、营养状况、炎症因子水平和并发症发生率。结果两组患者院外随访期间造瘘管更换率对比差异无统计学意义(P>0.05);治疗后,Introducer法组患者TSF、上臂肌围、FFMI、血红蛋白、白蛋白、前白蛋白水平均高于Pull法组(P<0.05);治疗后,Introducer法组IL-6水平、TNF-α水平均低于Pull法组(P<0.05);两组患者术后并发症总发生率对比差异无统计学意义(P>0.05)。结论Introducer法经皮内镜下胃造瘘术可以改善食管癌伴吞咽困难患者的自身营养水平,降低炎症反应水平。Objective To investigate the effects of introducer percutaneous endoscopic gastrostomy on nutritional indicators,inflammatory cytokine levels,and pathway infections in patients with esophageal cancer and dysphagia.Methods 96 patients with esophageal cancer and dysphagia admitted to the Department of Minimally Invasive Oncology from March 2020 to September 2022 were selected and were divided into the Pull method group and the Introducer method group according to their surgical methods.48 cases in the Pull method group were treated with Pull method percutaneous endoscopic stoma to establish an enteral nutrition pathway,while 48 cases in the Introducer method group were treated with Introducer method percutaneous endoscopic gastrostomy to establish an enteral nutrition pathway.The replacement rate of fistula tubes,nutritional status,levels of inflammatory factors,and incidence of complications between two groups of patients were compared.Results There was no statistically significant difference in the replacement rate of fistulas between the two groups of patients during outpatient follow-up(P>0.05).After treatment,the TSF,upper arm muscle circumference,FFMI,hemoglobin,albumin,and prealbumin levels in the Introducer group were higher than those in the Pull group(P<0.05);the levels of IL-6 and TNF-αin the Introducer group were all lower than those of the Pull group(P<0.05);There was no statistically significant difference in the total incidence of postoperative complications between the two groups of patients(P>0.05).Conclusion The Introducer percutaneous endoscopic gastrostomy can improve the nutritional status of patients with esophageal cancer and dysphagia,and reduce their levels of inflammatory response in the body.

关 键 词：Introducer法经皮内镜下胃造瘘术 食管癌 吞咽困难 营养指标 炎症因子 

分 类 号：R473.73[医药卫生—护理学]