[NiFe]-氢化酶仿生化学模拟合成研究进展  

Research progress in biomimetic chemical simulation synthesis of[NiFe]-hydrogenases

作　　者：马书修 崔晁瑜 甘贞洁 张宇 刘文博 MA Shu-xiu;CUI Chao-yu;GAN Zhen-jie;ZHANG Yu;LIU Wen-bo(School of Chemical and Printing-Dyeing Engineering,Henan University of Engineering,Zhengzhou 451191,China)

机构地区：[1]河南工程学院化工与印染工程学院,河南郑州451191

出　　处：《化学研究与应用》2024年第3期458-464,共7页Chemical Research and Application

基　　金：河南省高等学校大学生创新训练计划项目(202211517001)资助;河南工程学院博士培育基金项目(D2021013)资助。

摘　　要：介绍了氢化酶家族中重要的成员之一[NiFe]-氢化酶的活性中心结构和催化机理。综述了[NiFe]-氢化酶的双金属活性中心结构仿生化学模拟合成研究工作,一些具有代表性的[NiFe]-氢化酶模型物的合成方法和结构信息进行了描述。分析了近期研究者对[NiFe]-氢化酶仿生化学模拟合成研究的方向与重点,以及在[NiFe]-氢化酶仿生化学模拟合成工作上取得的一些成果,最后展望了[NiFe]-氢化酶模型物的未来发展前景与意义,为[NiFe]-氢化酶仿生化学研究提供参考。The active center structure and catalytic mechanism of[NiFe]-hydrogenases,one of the important members of hydrogenase family,were introduced.In this paper,the biomimetic chemical simulation of [NiFe]-hydrogenases bimetallic active center structure was introduced.Some representative[NiFe]-hydrogenase models were synthesized and their structure information was described.The research direction and focus of[NiFe]-hydrogenases biomimetic chemical simulation synthesis were analyzed,and some achievements were made in [NiFe]-hydrogenase biomimetic chemical simulation synthesis.Finally,the future development prospect and significance of[NiFe]-hydrogenase models were summarized,which could provide reference for the research of[NiFe]-hydrogenase biomimetic chemistry.

关 键 词：氢化酶 [NiFe]-氢化酶 [NiFe]-氢化酶模型物 生物酶制氢 仿生化学合成 

分 类 号：O627.8[理学—有机化学]