苯并噻唑酰腙类荧光探针合成及对锌离子检测  

Synthesis of a benzothiazolylhydrazone-based fluorescent probe for detection of Zn^(2+)

作　　者：刘其业 杨津涛 于思源 徐润祺 刘悦美 曾运波 喻艳超 LIU Qi-ye;YANG Jin-tao;YU Si-yuan;XU Run-qi;LIU Yue-mei;ZENG Yun-bo;YU Yan-chao(Key Laboratory of Green Chemical Engineering and Technology of College of Heilongjiang Province,College of Materials Science and Chemical Engineering,Harbin University of Science and Technology,Harbin 150080,China)

机构地区：[1]哈尔滨理工大学材料科学与化学工程学院,绿色化工技术黑龙江省高校重点实验室,黑龙江哈尔滨150080

出　　处：《化学研究与应用》2024年第3期565-571,共7页Chemical Research and Application

基　　金：黑龙江省自然科学基金项目(LH2021H001)资助;黑龙江省大学生创新创业训练计划项目(S202210214059)资助。

摘　　要：以苯并噻唑-2-甲酰肼与4-二乙胺基水杨醛为原料,设计并合成一种新型苯并噻唑酰腙类荧光探针L,并通过核磁、红外及质谱等手段表征。在DMSO溶液中,探针L可迅速与Zn^(2+)以1:1比例络合成L-Zn^(2+),实现对锌离子的即时荧光增强响应,且这一过程不受常见阳离子与阴离子的干扰。荧光滴定实验中计算出探针L对锌离子的检测极限低至15.8 nM,具有良好的检测灵敏度。探针L可实现土壤中锌离子的便捷、高效检测,加标回收率为95.72~103.20%,相对标准偏差为1.79~5.92%。A novel benzothiazolylhydrazide-based fluorescent probe L was designed and synthesized from benzothiazole-2-carbohydrazide and 4-diethylaminosalicylaldehyde,and characterized by NMR,IR and HRMS.In DMSO solution,probe L could rapidly form complexes L-Zn^(2+) with Zn^(2+) in a 1:1 ratio,which realized the immediate fluorescence-enhanced response to Zn^(2+),and the process was not interfered by common cations or anions.Detection limit of probe L for Zn2+was calculated to be as low as 15.8 nM in fluorescence titration experiments with a good detection sensitivity.Probe L could realize convenient and efficient detection of Zn^(2+)in soil with recovery rate of standard addition was 95.72~103.20%,and the relative standard deviation was 1.79~5.92%.

关 键 词：荧光探针 Zn^(2+) 光谱分析 苯并噻唑酰腙 

分 类 号：O614.31[理学—无机化学]