1-溴-9-芴酮的合成研究  

Synthesis research of 1-bromo-9H-fluoren-9-one

作　　者：王玉华 庞纪彩 王坤 李环 张成新 WANG Yu-hua;Pang Ji-cai;WANG Kun;LI Huan;ZHANG Cheng-xin(Basic Teaching Department,Shandong Vocational Animal Science and Veterinary College,Weifang 261061,China;Shandong Key Laboratory of Marine Fine Chemicals,Shandong Ocean Chemical Industry Scientific Research Institute,Weifang 262737,China)

机构地区：[1]山东畜牧兽医职业学院基础教学部,山东潍坊261061 [2]山东省海洋精细化工重点实验室,山东省海洋化工科学研究院,山东潍坊262737

出　　处：《化学研究与应用》2024年第3期663-667,共5页Chemical Research and Application

摘　　要：1-溴-9-芴酮是一种重要的有机光电材料中间体。本文以2-溴苯甲酸甲酯、苯硼酸、1,2-二溴乙烷为原料,经Suzuki偶联反应、酯水解反应、邻位金属化反应、分子内环化反应得到目标化合物,产物结构经^(1)H NMR和GC-MS确证。本文采用的合成方法简单、产品收率及纯度高,总收率达69.3%,GC纯度达到99.5%,适合规模化生产。1-Bromo-9H-fluoren-9-one is an important intermediate of organic photoelectric materials.In this paper,the target compound was obtained by the reaction of Suzuki cross-coupling reaction,ester hydrolysis,directed ortho metalation,and intramolecular cyclization reaction,using methyl 2-bromobenzoate,phenylboronic acid and 1,2-dibromoethane as starting material.The structure of product was confirmed by ~1H NMR and GC-MS.The synthesis route adopted in this paper had the advantages of simple synthesis method,high product yield and purity.The total yield was up to 69.3%,GC purity was reached 99.5%.This process was suitable for large-scale industrial production.

关 键 词：1-溴-9-芴酮 邻位金属化 SUZUKI偶联反应 合成方法 

分 类 号：O625.29[理学—有机化学]