民族药毛大丁草化学成分研究  

Chemical Constituents of Ethnodrug Gerbera piloselloides

作　　者：高奇 杨柳[2] 李齐激[1,2] 文雯 周浪[1,2] 杨小生 杨娟 GAO Qi;YANG Liu;LI Qi-ji;WEN Wen;ZHOU Lang;YANG Xiao-sheng;YANG Juan(State Key Laboratory of Functions and Applications of Medicinal Plants,Guizhou Medical University,Guiyang 550014,China;Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences,Guiyang 550014,China)

机构地区：[1]贵州医科大学省部共建药用植物功效与利用国家重点实验室,贵州贵阳550014 [2]贵州省中国科学院天然产物化学重点实验室,贵州贵阳550014

出　　处：《中药材》2023年第7期1688-1692,共5页Journal of Chinese Medicinal Materials

基　　金：贵州省科技创新能力建设专项(黔科合服企[2020]4013);贵州省天然产物高效利用工程研究中心(黔财建[2019]303);贵州食药用生物资源可持续利用特色重点实验室(黔教合KY字[2020]018)。

摘　　要：目的:研究民族药毛大丁草Gerbera piloselloides(L.)Cass.的化学成分。方法:利用硅胶柱色谱、重结晶以及制备型HPLC等技术对毛大丁草的醇提物进行分离、纯化,采用NMR、MS波谱技术对化合物进行结构鉴定。结果:从毛大丁草的醇提物中分离得到20个化合物,分别鉴定为:3,5-bis(3,3-dimethylallyl)-4-hydroxyacetophen-one(1)、2-[(2S^(*))-6-acetyl-2,3-dihydro-5-ydroxybenzofuran-2-yl]prop-2-enyl-3-methylbutanoate(2)、adian-5-en-3α-ol(3)、烟曲霉三唑酯A(4)、亚油酸甲酯(5)、芝麻素(6)、5-acetyl-2-(2-hydroxyisopropyl)-7-(3,3-dimethylallyl)-2,3-dihydrobenzofuran(7)、shearene A(8)、4-羟基苯乙酮(9)、对羟基苯甲醛(10)、山柰酚(11)、3-吲哚甲醛(12)、熊果醛(13)、咖啡酸乙酯(14)、2,5-二羟基苯乙酮(15)、木犀草素(16)、咖啡酸(17)、阿魏酸(18)、熊果苷(19)、对苯二酚(20)。结论:其中,化合物1~14为首次从该植物中分离得到。Objective:To study the chemical constituents of Gerbera piloselloides.Methods:The compounds from the ethanol extract of Gerbera piloselloides were isolated and purified by silica gel column chromatography,preparation liquid phase and recrystallization methods.The structures of the compounds were identified by NMR,MS spectrometry.Results:Twenty compounds were isolated from the ethanol extract of Gerbera piloselloides and identified as 3,5-bis(3,3-dimethylallyl)-4-hydroxyacetophen-one(1),2-[(2S^(∗))-6-acetyl-2,3-dihydro-5-ydroxybenzofuran-2-yl]prop-2-enyl-3-methylbutanoate(2),adian-5-en-3α-ol(3),aspergillus triazolate A(4),methyl lino-leate(5),sesamin(6),5-acetyl-2-(2-hydroxyisopropyl)-7-(3,3-dimethylallyl)-2,3-dihydrobenzofuran(7),shearene A(8),4-hydroxyacetophenone(9),4-hydroxybenzaldehyde(10),kaempferol(11),1H-indole-3-carboxaldehyde(12),ursolic aldehyde(13),ethyl caffeate(14),2,5-dihydroxyacetophenone(15),luteolin(16),caffeic acid(17),ferulic acid(18),arbutin(19),hydroquinone(20),respectively.Conclusion:Among them,compounds 1 to 14 are isolated from Gerbera piloselloides for the first time.

关 键 词：毛大丁草 化学成分 分离鉴定 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]