裕丹参乙酸乙酯部位化学成分研究  

Chemical Constituents from Ethyl Acetate Extract of Salvia miltiorrhiza in Fangcheng,Henan

作　　者：赵炳贤 任英杰 曹彦刚 李向达 刘晏灵 郑晓珂 冯卫生 ZHAO Bing-xian;REN Ying-jie;CAO Yan-gang;LI Xiang-da;LIU Yan-ling;ZHENG Xiao-ke;FENG Wei-sheng(College of Pharmacy,Henan University of Chinese Medicine/The Engineering and Technology Center for Chinese Medicine Development of Henan Province,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学药学院/河南省中药开发工程技术研究中心,河南郑州450046

出　　处：《中药材》2023年第7期1697-1700,共4页Journal of Chinese Medicinal Materials

基　　金：中央引导地方科技发展专项(豫财科[2016]149号)。

摘　　要：目的:研究裕丹参的化学成分。方法:利用硅胶、Sephadex LH-20葡聚糖凝胶、半制备HPLC等多种色谱方法对裕丹参50%丙酮提取物进行分离纯化,根据化合物理化性质和波谱特征进行结构鉴定。结果:从裕丹参干燥根和根茎中分离得到11个化合物,分别鉴定为:nimbidiol(1)、1S-hydroxy-anhydride of 16R-cryptotanshinone(2)、grandifolia C(3)、perovskiaol(4)、2-(3,4-dihydroxyphenyl)-5-formyl-1,3-benzodioxole(5)、secoisolariciresinol(6)、异落叶松脂素(7)、2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-5-benzofuranpropanol(8)、黑麦草内酯(9)、3-oxo-α-ionone(10)、催吐萝芙木醇(11)。结论:以上化合物均为首次从该植物中分离得到。Objective:To study the chemical constituents of Salvia miltiorrhiza from Fangcheng,Henan.Methods:The chemical constituents of 50%acetone extract of Salvia miltiorrhiza from Fangcheng,Henan were isolated and purified by silica gel,Sephadex LH-20,semi-preparative HPLC and other methods,the structures of the compounds were identified according to the physiochemical proper-ties and spectral data.Results:Eleven compounds were isolated from Salvia miltiorrhiza roots and rhizomes and identified as nimbidiol(1),1S-hydroxy-anhydride of 16R-cryptotanshinone(2),grandifolia C(3),perovskiaol(4),2-(3,4-dihydroxyphenyl)-5-formyl-1,3-benzodioxole(5),secoisolariciresinol(6),isolariciresinol(7),2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-me-thoxy-5-benzofuranpropanol(8),loliolide(9),3-oxo-α-ionone(10),vomifoliol(11),respectively.Conclusion:All compounds are isola-ted from Salvia miltiorrhiza for the first time.

关 键 词：裕丹参 提取分离 丹参酮类 倍半萜类 木脂素类 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]