血清FT_(3)、FT_(4)水平对甲亢患者并发甲亢性心脏病的评估价值  

Evaluation Value of FT_(3) and FT_(4) Levels in Patients with Hyperthyroidism Complicated with Hyperthyroid Heart Disease

作　　者：李丹 黄峰 LI Dan;HUANG Feng(Department of Clinical Laboratory,Chang'an District Hospital,Xi'an Shaanxi 710119)

机构地区：[1]西安市长安区医院检验科,陕西西安710119 [2]西安铁路疾病预防控制所检验科,陕西西安710054

出　　处：《医学临床研究》2024年第3期368-370,374,共4页Journal of Clinical Research

摘　　要：【目的】探讨血清游离三碘甲腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))对甲状腺功能亢进(简称甲亢)患者并发甲亢性心脏病的评估价值。【方法】选取2021年1月至2023年1月西安市长安区医院收治84例的甲亢患者,依据甲亢患者是否并发甲亢性心脏病分为并发组(n=10)和未并发组(n=74)。比较两组患者临床资料;采用Logistic多因素回归分析甲亢患者并发甲亢性心脏病的影响因素;采用受试者工作特征(ROC)曲线分析FT_(3)、FT_(4)及两者联合检测对甲亢患者并发甲亢性心脏病的评估效能。【结果】甲亢患者并发甲亢性心脏病发生率为11.90%(10/84)。两组性别、年龄、合并糖尿病、吸烟史、使用甲亢药物、尿酸、甘油三酯、血红蛋白、白蛋白、合并感染占比比较,差异均无统计学意义(P>0.05);并发组FT_(3)、FT_(4)水平均高于未并发组(P<0.05)。多因素分析结果显示:FT_(3)、FT_(4)均是甲亢患者并发甲亢性心脏病的影响因素(OR=3.256、3.368,P<0.05)。FT_(3)、FT_(4)预测甲亢患者并发甲亢性心脏病的最佳截断值分别为10.25 pmol/L、36.52 pmol/L,曲线下面积(AUC)分别为0.785、0.756,两者联合评估的特异度为92.69%,高于FT_(3)、FT_(4)单独进行评估的特异度(P<0.05)。【结论】甲亢患者并发甲亢性心脏病发生率较高,FT_(3)、FT_(4)对甲亢患者并发甲亢性心脏病具有一定的评估价值,且两者联合评估价值更高,可作为临床评估甲亢患者并发甲亢性心脏病的重要参考指标。【Objective】To explore the evaluation value of serum free triiodothyronine(FT_(3))and free thyroxine(FT_(4))in patients with hyperthyroidism complicated with hyperthyroid heart disease.【Methods】A total of 84 patients with hyperthyroidism treated in Chang'an District Hospital from January 2021 to January 2023 were selected in the study.The incidence of hyperthyroidism patients complicated with hyperthyroidism heart disease was counted,and patients were divided into concurrent group(10 cases)and non-concurrent group(74 cases)according to whether hyperthyroidism heart disease occurred.The clinical data of patients in concurrent group and non-concurrent group were compared.Multivariate logistic regression analysis was used to analyze the risk factors of hyperthyroidism patients complicated with hyperthyroidism heart disease.The efficacy of FT_(3) and FT_(4) in the evaluation of hyperthyroidism patients complicated with hyperthyroidism heart disease was analyzed.【Results】There were 10 cases of hyperthyroid patients complicated with hyperthyroid heart disease,which showed that the incidence of hyperthyroid heart disease was 11.90%.There were no significant differences in gender,age,diabetes mellitus,smoking history,hyperthyroidism drug use,uric acid,triglyceride,hemoglobin,albumin and infection between the concurrent group and the non-concurrent group(P>0.05).FT_(3) and FT_(4) in the concurrent group were higher than those in the non-concurrent group(P<0.05).The results of multivariate analysis showed that both FT_(3) and FT_(4) were independent risk factors for hyperthyroid patients complicated with hyperthyroid heart disease(OR=3.256,3.368,P<0.05).The best cutoff points of FT_(3) and FT_(4) in predicting hyperthyroidism complicated with hyperthyroidism heart disease were 10.25 pmol/L and 36.52 pmol/L respectively,and the area under the curve(AUC)was 0.785 and 0.756.The specificity of the combination of FT_(3) and FT_(4) was 92.69%,which was higher than that of FT_(3) and FT_(4) alone(P<0.05).【Conclusion�

关 键 词：甲状腺功能亢进症/并发症 心脏病/病因学 三碘甲状腺原氨酸/血液 甲状腺素/血液 

分 类 号：R581.1[医药卫生—内分泌]