血清乙型肝炎病毒表面抗原水平与血清乙型肝炎病毒脱氧核糖核酸载量在不同阶段乙型肝炎病毒感染肝衰竭患者中的表达  

Expression of serum hepatitis B virus surface antigen level and serum hepatitis B virus deoxyribonucleic acid load in patients with liver failure at different stages of hepatitis B virus infection

作　　者：卢志华 黄文滨 张满娥[1] 邓巧芳 LU Zhihua;HUANG Wenbin;ZHANG Man′e;DENG Qiaofang(Molecular Biology Laboratory,the Second Hospital of Longyan,Fujian Province,Longyan364000,China)

机构地区：[1]福建省龙岩市第二医院分子生物实验室,福建龙岩364000

出　　处：《中国当代医药》2024年第8期114-117,共4页China Modern Medicine

摘　　要：目的分析血清乙型肝炎病毒表面抗原(HBsAg)水平与血清乙型肝炎病毒脱氧核糖核酸(HBV-DNA)载量在不同阶段乙型肝炎病毒(HBV)感染肝衰竭患者中的表达意义。方法回顾性选取龙岩市第二医院于2020年9月至2021年9月收治的64例HBV感染肝衰竭患者作为研究对象,按照病情阶段分为慢性肝衰竭(CLF)组35例和慢加急性肝衰竭(ACLF)组29例,两组均通过电化学发光法和荧光定量法(Q-PCR)检测血清中HBsAg和HBV-DNA水平,并比较两组的因子表达情况。结果ACLF组中的HBsAg与HBV-DNA水平以及CD4+、CD8+均高于CLF组,差异有统计学意义(P<0.05)。结论临床可通过分析患者血清中的HBsAg与HBV-DNA水平的表达情况,掌握不同病程阶段HBV感染患者的病情进展情况,为病症的预防和干预治疗提供参考依据。Objective To analyze the expression significance of serum hepatitis B virus surface antigen(HBsAg)level and serum hepatitis B virus deoxyribonucleic acid(HBV-DNA)load in patients with liver failure infected by hepatitis B virus(HBV)at different stages.Methods A total of 64 patients with HBV infected liver failure treated in the Second Hospital of Longyan from September 2020 to September 2021 were retrospectively selected as research objects and they were divided into 35 patients in chronic liver failure(CLF)group and 29 patients in chronic plus acute liver failure(ACLF)group according to the stage of illness.The levels of HBsAg and HBV-DNA in serum were detected by electrochemiluminescence and fluorescence quantitative analysis(Q-PCR)in both groups,and the expression of factors in the two groups were compared.Results The levels of HBsAg,HBV-DNA,CD4+and CD8+in ACLF group were higher than those in CLF group,and the differences were statistically significant(P<0.05).Conclusion In clinical practice,we can analyze the expression of HBsAg and HBV DNA levels in patients'serum,master the progress of patients with HBV infection at different stages of the disease course,and provide reference for disease prevention and intervention.

关 键 词：乙型肝炎病毒表面抗原 乙型肝炎病毒脱氧核糖核酸 乙型肝炎病毒 病理表达 

分 类 号：R512.62[医药卫生—内科学]