北京地区育龄男性与女性TORCH感染情况回顾分析  

An Investigation and Comparison of TORCH Infection in Male and Female Populations in Beijing Area

作　　者：陈陆[1] 谢杰施 陈怡菲 王殊 曹正 翟燕红[1] CHEN Lu;XIE Jieshi;CHEN Yifei;WANG Shu;CAO Zheng;ZHAI Yanhong(Department of Laboratory Medicine,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing Maternal and Child Health Care Hospital,Beijing 10026,China)

机构地区：[1]首都医科大学附属北京妇产医院/北京妇幼保健院,北京100026

出　　处：《标记免疫分析与临床》2024年第1期38-47,共10页Labeled Immunoassays and Clinical Medicine

基　　金：北京市属医院科研培育计划项目(编号:PX2020060);北京妇产医院青年基金(编号:FCYYQN-201703)。

摘　　要：目的 回顾分析近2016年7月至2022年12月来我院就诊人群的TORCH感染情况,为本地区优生优育工作提供数据参考。方法 利用酶联免疫吸附实验检测男性和非妊娠期女性血清中TORCH各病原体IgG抗体和IgM抗体的阳性情况,对数据进行处理分析。结果 进行TORCH检测的人群,女性人数远高于男性人数;男性和女性之间TOX、RV、CMV和HSV的IgM抗体阳性率均存在差异,男性和女性之间TOX和HSV的所有感染模式存在差异,且所有差异均表现为女性的抗体阳性率高于男性的抗体阳性率;男性RV和CMV的IgM抗体阳性率在不同的季节存在差异,女性的TOX、RV、CMV和HSV-1的IgM抗体阳性率在不同的季节存在差异;男、女性HSV-1和HSV-2抗体IgM阳性率在各季节均存在差异,且男、女性HSV-2的所有感染模式在各个季节中也完全不同;在合并感染中,男、女性的IgG抗体阳性率均以RV+CMV、RV+HSV-1、CMV+HSV-1和RV+CMV+HSV-1为主,且女性的抗体阳性率高于男性,在IgM抗体的阳性率分析中,女性主要以HSV-1+HSV-2为主,男性主要以RV+HSV-1为主,其女性的抗体阳性率也远高于男性。结论 本地区TORCH感染人群主要为女性,TORCH感染的病原体有季节性差异,可针对此特点进行预防;建议增加育龄男性检测TORCH相关项目,可有助于夫妇备孕期感染的预防。Objective To analyze TORCH infection in patients of our hospital in recent years,so as to provide a reference for the work of eugenic and eugenic care in Beijing area.Methods Male and non-pregnant women patients were selected as study subjects.Fasting blood was drawn from all subjects,and the serum was centrifuged.TORCH pathogen antibody IgG and IgM in serum were detected by enzyme-linked immunoreaction test,and the data were then processed and analyzed.Results A significant more women than men were tested by TORCH;IgM positive rates for TOX,RV,CMV and HSV were different between males and females,and all infection modes of TOX and HSV were different between males and females,with higher antibody positive rates in females than in males;The influence of different seasons on IgM positive rate in males was only shown in RV and CMV,while in females,IgM positive rate could affect TOX,RV,CMV and HSV-1;IgM positive rates of HSV-1 and HSV-2 in male and female were different in each season,and infection patterns of HSV-2 in male and female were different in each season;Co-infection analysis showed that RV+CMV,RV+HSV-1,CMV+HSV-1 and RV+CMV+HSV-1 were the main co-infection patterns of IgG positive in both males and females,and the IgG positive rate in females was higher than that in males.Positive rate analysis showed that IgM,HSV-1+HSV-2 and RV+HSV-1 were the main co-infection patterns.The antibody positive rate of female was much higher than that of male.Conclusion Within Beijing area,the population of TORCH infection is mainly women,while the pathogens are mainly RV,CMV,and HSV.The infection can be affected by seasonal factors.It is recommended to increase the testing of TORCH-related items for men of childbearing age,which can help couples prevent infection during pre-pregnancy period.

关 键 词：TORCH感染 阳性率 季节性 感染模式 合并感染类型 

分 类 号：R714.2[医药卫生—妇产科学]