早产儿早发性肺炎脂溶性维生素A、D、E水平现状及影响因素探讨  

The Current Status and Influencing Factors of Lipid Soluble Vitamin A,D and E Levels in Premature Infants with Pneumonia

作　　者：李丹 杨秀芳[2] 曾柳钰 LI Dan;YANG Xiufang;ZENG Liuyu(Guangdong Medical University,Zhanjiang 524023,China;Department of Neonatology,Zhongshan People’s Hospital,Guangdong Province,Zhongshan 528403,China)

机构地区：[1]广东医科大学,广东湛江524023 [2]广东省中山市人民医院新生儿科,广东中山528403

出　　处：《标记免疫分析与临床》2024年第1期58-62,98,共6页Labeled Immunoassays and Clinical Medicine

基　　金：2021年度广东省中医药局中医药科研项目立项项目(编号:20202257)。

摘　　要：目的 调查早产儿早发性肺炎脂溶性维生素A、D、E水平,并分析其影响因素。方法 本研究为单中心病例对照研究,选取了2022年11月至2023年6月期间在中山市人民医院新生儿监护室接受治疗的100例早产儿作为研究对象。根据早产儿是否发生肺炎将其分为肺炎组(n=50),称为观察组,并选取同期在我院治疗并出院的、无特殊病史的早产儿(n=50),称为对照组。采用高效液相色谱法来测试两组早产儿血清中的脂溶性维生素A、D、E的水平。比较两组早产儿和孕母临床资料,早产儿早发性肺炎患者影响因素分析采用Logistic回归模型。结果 观察组孕母胎膜早破以及患儿指标(性别、复苏史、采用呼吸辅助通气、出生体重、住院时长)明显高于对照组(P<0.05)。两组早产儿早期血清脂溶性维生素A、D、E水平显示,观察组维生素A、维生素E明显低对照组(P<0.05)。多因素Logistic回归分析结果显示,早产儿为女性、孕母有胎膜早破是早产儿肺炎的危险因素(P<0.05);而高血清维生素A、维生素E是早产儿肺炎的保护因素(P<0.05)。结论 早产儿早发性肺炎存在脂溶性维生素A、E水平缺乏的现状,而早产儿为女性、孕母有胎膜早破史及有血清脂溶性维生素A、E缺乏是早产儿肺炎的影响因素。Objective To investigate levels of lipid soluble vitamins A,D and E in premature infants with early-onset pneumonia and to identify their influencing factors.Methods This study was a single-center case-control study,by selecting 100 premature infants who received treatment in the Neonatal Care Unit of Zhongshan People’s Hospital from November,2022 to June,2023 as the study sample.Premature infants were divided into the pneumonia group(n=50)based on whether they developed pneumonia,collectively referred to as the observation group.Premature infants who were treated and discharged from our hospital at the same time and had no special medical history(n=50)were selected,collectively referred to as the control group.We used high-performance liquid chromatography to test the content of lipid soluble vitamins A,D and E in serum samples of two groups of premature infants.We compared the clinical data of two groups of premature infants and pregnant women,as well as indicators,including lipid soluble vitamin A,D and E levels.Logistic regression model was used to identify the influencing factors of premature pneumonia patients.Results The observation group showed significantly higher levels of premature rupture of membranes in pregnant women and children(gender,history of resuscitation,use of respiratory assistance ventilation,birth weight,length of hospitalization)compared to the control group(P<0.05).The early serum lipid soluble vitamin A,D and E levels in the two groups of premature infants showed that the observation group had significantly lower levels of vitamin A and vitamin E compared to the control group(P<0.05).Multivariate logistic regression analysis showed that female premature infants and premature rupture of membranes in pregnant women were risk factors for premature pneumonia(P<0.05),while high serum vitamin A and vitamin E were protective factors for premature pneumonia(P<0.05).Conclusion There is a lack of lipid soluble vitamin A and E levels in premature infants with early-onset pneumonia,and the prese

关 键 词：维生素A 维生素D 维生素E 早产儿 肺部感染 影响因素 

分 类 号：Q56[生物学—生物化学]