二硫键异构酶结构及生物学功能研究进展  

The Research Progress on Structure and Biological Function of Disulfide Isomerase

作　　者：张强[1,2] 王培昌[1] 杨婷婷[2] 吴燕丹 ZHANG Qiang;WANG Peichang;YANG Tingting;WU Yandan(Department of Clinical Laboratory,Xuanwu Hospital,Capital Medical University,Beijing,100053,China;Department of Clinical Laboratory,the Hospital of Shunyi District Beijing 101300,China)

机构地区：[1]首都医科大学宣武医院检验科,北京100053 [2]北京顺义区医院检验科,北京101300

出　　处：《标记免疫分析与临床》2024年第1期176-180,193,共6页Labeled Immunoassays and Clinical Medicine

基　　金：国家自然科学基金重点项目(编号:82030064);国家自然科学基金(编号:81871714)。

摘　　要：蛋白质二硫键异构酶具有酶和分子伴侣的生物学活性,在蛋白质合成、分泌的过程中具有重要作用。本文对其分子结构、生物学功能及其在血栓性疾病、肿瘤、神经退化性疾病发生发展中的功能机制进行了综述。Protein disulfide isomerase has the biological activity of enzyme and molecular chaperone,and can play an important role in the process of protein synthesis and secretion.This article reviews the recent research progress of its molecular structure,biological function and its underlying functional mechanism in the occurrence and development of thrombotic diseases,tumors and neurodegenerative diseases.

关 键 词：蛋白质二硫键异构酶 血栓性疾病 肿瘤 神经退化性疾病 

分 类 号：Q558[生物学—生物化学]