4-硝基苯甲酸甲酯合成工艺研究  

Synthesis Process of 4-Nitrobenzoic Acid Methyl Ester

作　　者：袁健豪 李金良 范瑞 张浩 王鲲鹏 YUAN Jianhao;LI Jinliang;FAN Rui;ZHANG Hao;WANG Kunpeng(College of Chemistry and molecular Engineering,Qingdao University of Science and Technology,Qi 266045,Shandong China;Taian Yuehai New Materials Co.,Ltd.,Taian 271600,Shandong China)

机构地区：[1]青岛科技大学化学与分子工程学院,青岛266042 [2]泰安岳海新材料股份有限公司,泰安271600

出　　处：《染料与染色》2024年第1期47-50,54,共5页Dyestuffs and Coloration

摘　　要：对以4-硝基苯甲酸为原料,合成4-硝基苯甲酸甲酯的生产路线进行了工艺优化。考察了催化剂、溶剂、温度、母液套用次数对反应的影响。优化的工艺条件为:发烟硫酸为催化剂,碳酸二甲酯为溶剂,回流温度反应10 h,母液套用5次,在此条件下,收率可达到94.7%。The production route for synthesizing 4-nitrobenzoic acid methyl ester from 4-nitrobenzoic acid was optimized.The effects of catalyst, solvent, temperature and recycling times of mother liquor on the reaction were investigated.The optimum conditions as follows: oleum as catalyst, dimethyl carbonate as solvent, reacted at reflux temperature for 10 h, and mother liquor recycled 5 times.Under these conditions, the yield could reach up to 94.7%.

关 键 词：4-硝基苯甲酸甲酯 4-硝基苯甲酸 碳酸二甲酯 酯化反应 工艺优化 绿色合成 

分 类 号：TQ612.2[化学工程—精细化工]