外泌体microRNA在糖尿病性心脏病中的研究进展  

Research progress of exosome-derived microRNA in diabetic heart disease

作　　者：孙玥 周奕廷 丁栩 郁志明[1] SUN Yue;ZHOU Yiting;DING Xu;YU Zhiming*(Department of Cardiology,Wuxi People’sHospital Affiliated to Nanjing Medical University,Wuxi 214023,China)

机构地区：[1]南京医科大学附属无锡市人民医院心血管内科,江苏无锡214023

出　　处：《南京医科大学学报（自然科学版）》2024年第4期573-578,594,共7页Journal of Nanjing Medical University(Natural Sciences)

基　　金：太湖人才计划高端人才(2020-THRC-GDYZM);江苏省卫健委老年健康科研课题(LKM2023031);新“三名”战略项目高端人才培育(2023XSMZL-GD-YZM-2023)。

摘　　要：外泌体微小核糖核酸(microRNA,miRNA)是由外泌体介导分泌的一类非编码单链RNA,通过抑制信使RNA的翻译在转录后改变蛋白质表达。糖尿病时,基因编码区发生的改变会导致miRNA表达的变化,这些变化诱导诸如氧化应激、线粒体功能障碍、心肌细胞凋亡与焦亡、血管重塑、纤维化等一系列病理生理改变,进而参与糖尿病性心脏病的发生发展。文章就外泌体miRNA的特性,及其在糖尿病性心脏病中的作用和治疗潜力进行综述。Exosome-derived microRNAs(miRNA)are a class of non-coding single-stranded RNA secreted by exosomes,which alter protein expression by inhibiting the translation of messenger RNA.In diabetes,alterations in the coding regions of genes lead to changes in miRNA expression.These variations induce a series of pathophysiological changes,such as oxidative stress,mitochondrial dysfunction,myocardial apoptosis and pyroptosis,vascular remodeling,and fibrosis,thereby participating in the occurrence and development of diabetic heart disease.This article reviews the characteristics of exosome-derived miRNAs and summarizes their roles and therapeutic potential in diabetic heart disease.

关 键 词：糖尿病性心脏病 外泌体 微小核糖核酸 

分 类 号：R541.9[医药卫生—心血管疾病]