免疫球蛋白A肾病患者血清FUT8水平与肾小管间质损伤相关性分析  

Correlation analysis of serum FUT8 level and tubulointerstitial injury in patients with immunoglobulin A nephropathy

作　　者：姜欣佐 宋国良 田雪山 JIANG Xinzuo;SONG Guoliang;TIAN Xueshan(Department of Clinical Laboratory,Hongda Hospital of Jiamusi University,Jiamusi,Heilongjiang 154000,China;Department of Clinical Laboratory,Jiamusi Central Hospital,Jiamusi,Heilongjiang 154002,China)

机构地区：[1]佳木斯大学宏大医院检验科,黑龙江佳木斯154000 [2]佳木斯中心医院检验科,黑龙江佳木斯154002

出　　处：《国际检验医学杂志》2024年第7期809-812,817,共5页International Journal of Laboratory Medicine

基　　金：黑龙江省医药卫生科研课题(2019-163)。

摘　　要：目的探讨免疫球蛋白A肾病(IgAN)患者血清α1-6-岩藻糖基转移酶(FUT8)水平与肾小管间质损伤的关系。方法选取2020年3月至2022年12月佳木斯大学宏大医院收治的89例IgAN患者作为IgAN组和63例性别和年龄匹配的健康志愿者作为对照组。根据小管萎缩及间质纤维化(T)分级将IgAN组患者分为T0组(28例)、T1组(39例)、T2组(22例),根据间质性炎症指数(Inf I)将患者分为轻度组(0~1分,30例)、中度组(2~3分,42例)、重度组(4分,17例)。检测各组血清FUT8水平,并分析血清FUT8水平与IgAN临床参数、T分级、Inf I的相关性。结果IgAN组收缩压、血肌酐、尿素氮、FUT8水平高于对照组(P<0.05),血清白蛋白和估算肾小球滤过率(eGFR)低于对照组(P<0.05)。不同T分级、间质性炎症细胞浸润程度IgAN患者血清FUT8水平比较差异有统计学意义(P<0.05),T2组血清FUT8水平高于T1组和T0组(P<0.05),重度组血清FUT8水平高于中度组、轻度组(P<0.05)。IgAN患者血清FUT8水平与血肌酐、T分级、Inf I呈正相关(P<0.05),与eGFR呈负相关(P<0.05)。结论IgAN患者血清FUT8水平升高,且与肾小管间质损伤加重、肾功能下降有关。Objective To investigate the relationship between serumα1-6 fucosyltransferase(FUT8)level and tubulointerstitial injury in patients with immunoglobulin A nephropathy(IgAN).Methods A total of 89 IgAN patients admitted to Hongda Hospital of Jiamusi University from March 2020 to December 2022 were selected as IgAN group,and 63 gender-and age-matched healthy volunteers were selected as control group.According to tubule atrophy and interstitial fibrosis(T)grade,IgAN patients were divided into T0 group(28 cases),T1 group(39 cases)and T2 group(22 cases).Meanwhile,according to interstitial inflammation index(Inf I),the patients were divided into mild group(0-1 points,30 cases),moderate group(2-3 points,42 cases)and severe group(4 points,17 cases).The serum FUT8 level of the each group was detected,and the correlation between serum FUT8 level and IgAN clinical parameters,T grade and Inf I was analyzed.Results The levels of systolic blood pressure,serum creatinine,urea nitrogen and FUT8 in IgAN group were higher than those in control group(P<0.05),and serum albumin and estimated glomerular filtration rate(eGFR)in IGAN group were lower than those in control group(P<0.05).The serum FUT8 level in IgAN patients with different T grades and degrees of interstitial inflammatory cell infiltration had statistical significance(P<0.05).The serum FUT8 level in T2 group was higher than that in T1 and T0 groups(P<0.05),and the serum FUT8 level in severe group was higher than that in moderate and mild groups(P<0.05).Serum FUT8 level in IgAN patients was positively correlated with serum creatinine,T grade and Inf I(P<0.05),and negatively correlated with eGFR(P<0.05).Conclusion Serum FUT8 level is significantly increased in IgAN patients,which is related to the aggravation of renal tubulointerstitial injury and the decline of renal function.

关 键 词：免疫球蛋白A肾病 肾小管间质损伤 α1-6-岩藻糖基转移酶 炎症 肾间质纤维化 

分 类 号：R446.6[医药卫生—诊断学] R692[医药卫生—临床医学]