戊型肝炎的实验室诊断指标与临床应用  

Laboratory diagnosis and clinical applications of hepatitis E

作　　者：应东 夏宁邵[1] 郑子峥[1] Ying Dong;Xia Ningshao;Zheng Zizheng(National Institute of Diagnostics and Vaccine Development in Infectious Diseases,NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology,School of Public Health(School of Life Sciences),Xiamen University,Xiamen 361104,China)

机构地区：[1]厦门大学公共卫生学院/生命科学学院,国家传染病诊断试剂与疫苗工程技术研究中心,国家药监局传染性疾病检测技术研究与评价重点实验室,厦门361104

出　　处：《中华检验医学杂志》2024年第3期210-215,共6页Chinese Journal of Laboratory Medicine

基　　金：国家自然科学基金(32370160);福建省自然科学基金(2022J02005)。

摘　　要：戊型肝炎病毒(HEV)感染引起的戊型肝炎已成为我国最主要的急性病毒性肝炎之一。近年来HEV各检测指标, 包括HEV RNA、HEV抗原、抗-HEV IgM及抗HEV-IgG等指标, 在方法学上有了新进展及在实验室诊断中有了新发现。急性戊型肝炎患者、慢性戊型肝炎患者、肝外临床症状患者诊断以及病原体携带者、相关职业体检人员检测等不同人群中应进行多指标联合诊断。不同人群各指标检测结果有各自的临床意义。Hepatitis E virus(HEV)is the major pathogen responsible for acute viral hepatitis in China.Recently,there have been new advances in the methodologies and novel discoveries in the laboratory diagnosis of HEV,including various diagnostic markers such as HEV RNA,HEV antigen,anti-HEV IgM,and anti-HEV IgG.A multi-indicator diagnostic approach should be applied across different populations,including patients with acute or chronic hepatitis E,individuals with extra-hepatic clinical symptoms,asymptomatic carriers,and specific occupational groups undergoing health assessments.The clinical significance of test results for each marker varies among these different groups.

关 键 词：肝炎病毒 戊型 戊型肝炎抗体 戊型肝炎抗原 病原学诊断 

分 类 号：R512.6[医药卫生—内科学]