多索茶碱联合N-乙酰半胱氨酸治疗稳定期慢阻肺的效果  

Effect of Doxofylline Combined with N-acetylcysteine in Treatment of Stable COPD

作　　者：李欣 郭宏杰[1] Li Xin;GUO Hongjie(Respiratory Intensive Care Unit,the First Affiliated Hospital of Nanyang Medical College,Nanyang 473000,China)

机构地区：[1]南阳医学高等专科学校第一附属医院呼吸与危重症医学科,河南南阳473000

出　　处：《临床医学工程》2024年第3期327-328,共2页Clinical Medicine & Engineering

摘　　要：目的探讨多索茶碱联合N-乙酰半胱氨酸治疗稳定期慢阻肺(COPD)的临床效果。方法选取2022年6月至2023年5月本院收治的90例COPD患者,按照抽签法分为观察组与对照组。对照组采用多索茶碱治疗,观察组采用多索茶碱联合N-乙酰半胱氨酸治疗。比较两组的治疗效果、肺通气指标、炎性因子水平。结果观察组总有效率为95.56%,高于对照组的80.00%(P<0.05)。治疗后,观察组PaO_(2)、FVC、FEV1水平高于对照组,PaCO_(2)水平低于对照组(P<0.05)。治疗后,观察组CRP、PCT水平低于对照组(P<0.05)。结论多索茶碱联合N-乙酰半胱氨酸治疗稳定期COPD的效果理想,可改善患者的肺功能,抑制炎性因子水平。Objective To explore the clinical effect of doxofylline combined with N-acetylcysteine in the treatment of stable COPD.Methods 90 COPD patients admitted to our hospital from June 2022 to May 2023 were selected and divided into observation group and control group according to lottery method.The control group was treated with doxofylline,and the observation group was treated with doxofylline combined with N-acetylcysteine.The treatment effect,pulmonary ventilation indicators and inflammatory factor levels were compared between the two groups.Results The total effective rate of the observation group was 95.56%,higher than 80.00%of the control group(P<0.05).After treatment,the PaO_(2),FVC and FEV1 levels of the observation group were higher than those of the control group,and the PaCO_(2) level was lower than that of control group(P<0.05).After treatment,the CRP and PCT levels of the observation group were lower than those of the control group(P<0.05).Conclusions Doxofylline combined with N-acetylcysteine in the treatment of stable COPD has ideal effect,which can improve the lung function and inhibit the levels of inflammatory factors.

关 键 词：多索茶碱 N-乙酰半胱氨酸 慢阻肺 

分 类 号：R563.9[医药卫生—呼吸系统]