噻托溴铵粉吸入剂联合阿奇霉素治疗稳定期支气管扩张症的疗效  

Efficacy of tiotropium bromide powder inhalant combined with azithromycin in the treatment of stable bronchiectasis

作　　者：邓玉冉 Deng Yu-ran(Department of Second Internal Medicine,The First People's Hospital of Wolong District,Nanyang 473000,Henan,China)

机构地区：[1]河南省南阳市卧龙区第一人民医院内二科,河南南阳473000

出　　处：《四川生理科学杂志》2024年第3期636-638,共3页Sichuan Journal of Physiological Sciences

摘　　要：目的:探讨噻托溴铵粉吸入剂联合阿奇霉素治疗稳定期支气管扩张症的疗效.方法:选取2020年6月-2022年6月医院收治的90例稳定期支气管扩张症患者作为研究对象.采用交替分组法将患者分为对照组和观察组,每组各45例.对照组采用阿奇霉素治疗.观察组在对照组基础上联合噻托溴铵粉吸入剂治疗.分析比较两组治疗前、治疗3 m后炎性指标、肺功能、不良反应发生情况.结果:与治疗前比较,两组治疗3 m后肿瘤坏死因子-α(TNF-α)、白细胞介素-17(IL-17)水平均降低,且观察组较对照组低(P<0.05);与治疗前比较,两组治疗3 m后第1 s用力呼气容积(FEV1)、第一秒用力呼气容积占用力肺活量的百分比(FEV1/FVC)均升高,且观察组较对照组高(P<0.05);两组不良反应发生率对比,差异无统计学意义(P>0.05).结论:噻托溴铵粉吸入剂联合阿奇霉素治疗稳定期支气管扩张症,可减轻患者炎性反应,提高肺功能,且安全性较高.Objective:To investigate the efficacy of tiotropium bromide powder inhalation combined with azithromycin in the treatment of stable bronchiectasis.Methods:90 patients with stable bronchiectasis admitted to the hospital from June 2020 to June 2022 were selected as the study objects.The patients were divided into control group and observation group with 45 cases in each group.The control group was treated with azithromycin.Observation group was treated with tiotropium bromide powder inhalation on the basis of control group.The inflammatory indexes,lung function and adverse reactions of the two groups were analyzed and compared before and after 3 months of treatment.Results:Compared with before treatment,the levels of tumor necrosis factor-α(TNF-α)and interleukin-17(IL-17)in 2 groups were decreased after 3 months of treatment,and the observation group was lower than the control group(P<0.05).Compared with before treatment,the 1s forced expiratory volume(FEV1)and the percentage of the first second forced expiratory volume to forced vital capacity(FEV1/FVC)of both groups were increased after 3 months of treatment,and the observation group was higher than the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Tiotropium powder inhalation combined with azithromycin in the treatment of stable bronchiectasis can reduce inflammatory response and improve lung function,with high safety.

关 键 词：支气管扩张症 稳定期 噻托溴铵粉吸入剂 阿奇霉素 

分 类 号：R562.22[医药卫生—呼吸系统]