产后阴道微生态的定性系统评价  

Qualitative systematic evaluation of postpartum vaginal microecology

作　　者：闫梅[1] 王晓银 罗同勇 帅志容[1] 李宁[1] 王玉敏 Yan Mei;Wang Xiao-yin;Luo Tong-yong;Shuai Zhi-rong;Li Ning;Wang Yu-min(Sichuan Women and Children's Hospital,Sichuan Women and Children's Hospital,Chengdu 610000,China;The Affiliated Hospital ofChengdu University of Traditional Chinese Medicine,Chengdu 610000,China;Miyi Branch of Sichuan Maternal and Child Health Hospital,MiyiMaternal and Child Health Hospital,Panzhihua 610000,Sichuan,China)

机构地区：[1]四川省妇幼保健院﹒四川省妇女儿童医院,四川成都610000 [2]成都中医药大学附属医院,四川成都610000 [3]四川省妇幼保健院米易分院﹒米易县妇幼保健院,四川攀枝花610000

出　　处：《四川生理科学杂志》2024年第3期703-708,共6页Sichuan Journal of Physiological Sciences

摘　　要：目的:分析产后阴道微生态体系4项核心主题的变化,包含产后菌群结构特征、菌型(Communitystatetypes,CST)分布、生物多样性、与孕期及非孕期的差异性菌属。方法:使用Vaginal/Vaginas/Reproductivetract,Microbiota/Flora,Microbiome/Microbiotas/Microbial/Microbiome/Microbiomes,Postpartum Period/Postpartum/Puerperium在9个中英文数据库进行检索,共得出1783篇文献,最终筛选10篇文献纳入分析,并采用关键评价方案(Critical Appraisal Skills Program,CASP)工具进行文献质量评价。结果:10篇文章对4项核心主题纳入分析,产后生殖道菌群呈现特征性菌群结构,以厌氧菌为优势菌,多由CSTIII、CSTIV-A构成。产后的阴道微生态菌种多样性,与非孕期健康女性无明显差异,与妊娠期相比其α多样性和β多样性均最高。产后的乳酸杆菌丰度降低,而种类增多。结论:提示可对产后妇女尝试采取有效的治疗措施来,尽快改善产后阴道微环境向健康非孕期妇女转化。Objective:To analyze the changes in four core themes of postpartum vaginal microecosystem,including the structural characteristics of postpartum flora,the distribution of community state types(CST),biodiversity,and the differences between pregnant and non-pregnant bacterial genera.How:Using Vaginal/Vaginas/Reproductive tract Microbiota/Flora,Microbiome Microbiotas/Microbial/Microbiome/Microbiomes,Postpartum Period Postpartum/Puerperium in 9 Chinese English database retrieval,a total of 1783 articles,ultimately selected 10 articles were included in the analysis,Critical Appraisal Skills Program(CASP)was used to evaluate the quality of documents.Results:10 articles included 4 core topics in the analysis,the postpartum reproductive tract flora showed a characteristic flora structure,with anaerobic bacteria as the dominant bacteria,mostly composed of CST III and CST IV-A.The diversity of postpartum vaginal microecological bacteria was not significantly different from that of non-pregnant healthy women,and theαdiversity andβdiversity were the highest compared with pregnancy.The abundance of lactobacillus decreased after delivery,but the variety increased.Conclusion:It is suggested that effective treatment measures can be taken to improve the transformation of postpartum vaginal microenvironment to healthy non-pregnant women as soon as possible.

关 键 词：产后 阴道微生态 定性系统评价 

分 类 号：R714[医药卫生—妇产科学]