酒石酸布托诺啡联合右美托咪定在分娩镇痛中的应用效果  

Effects of Butonorphine Tartrate Combined with Dexmedetomidine in Labor Analgesia

作　　者：马青[1] 于艳宏 孔令杰[1] MA Qing;YU Yanhong;KONG Lingjie(Department of Anesthesiology,Tianjin Shuige Hospital,Tianjin 300000,China;Department of Anesthesiology,Chinese People's Armed Police Force Characteristic Medical Center,Tianjin 300160,China)

机构地区：[1]天津市水阁医院麻醉科,天津300000 [2]中国人民武装警察部队特色医学中心麻醉科,天津300160

出　　处：《中国药物滥用防治杂志》2024年第2期204-207,共4页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:探讨酒石酸布托诺啡联合右美托咪定在分娩镇痛中的应用效果。方法:选择2019年6月—2022年6月在本院进行建档自然分娩的产妇124例作为研究对象,按照随机数字表法分为联合组62例与对照组62例。对照组给予右美托咪定的硬膜外镇痛,联合组给予酒石酸布托诺啡联合右美托咪定的硬膜外镇痛,比较两组疼痛程度、产程时间、不良反应发生率及母婴结局。结果:联合组产后4、8、12、24 h疼痛VAS评分低于对照组(P<0.05);联合组第一产程、第二产程与第三产程时间短于对照组(P<0.05);联合组产后24 h不良反应发生率低于对照组(P<0.05);联合组产妇与新生儿不良结局发生率低于对照组(P<0.05)。结论:酒石酸布托诺啡联合右美托咪定在分娩镇痛中能降低产妇的疼痛程度,缩短产程时间,降低产妇不良反应发生率,还可改善母婴结局。Objective:To investigate the effect of buprenorphine tartrate combined with dexmedetomidine in labor analgesia.Methods:One hundred and twenty-four cases of women who underwent natural delivery in our hospital from June 2019 to June 2022 were selected for the study and were divided into 62 cases in the combined group and 62 cases in the control group according to the random number table method.The control group was given epidural analgesia with dexmedetomidine and the combined group was given epidural analgesia with buprenorphine tartrate combined with dexmedetomidine,and the pain level,duration of labor,incidence of adverse effects and maternal and infant outcomes were compared between the two groups.Results:The pain VAS scores at 4,8,12,and 24 h after delivery were lower in the combined group than in the control group(P<0.05);the duration of the first,second,and third stages of labor was shorter in the combined group than in the control group(P<0.05);the incidence of adverse events at 24 h after delivery was lower in the combined group than in the control group(P<0.05);and the incidence of adverse maternal and neonatal outcomes was lower in the combined group than in the control group(P<0.05).Conclusion:Buprenorphine tartrate combined with dexmedetomidine in labor analgesia reduces the level of maternal pain,shortens the duration of labor,reduces the incidence of maternal adverse effects,and also improves maternal and infant outcomes.

关 键 词：酒石酸布托诺啡 右美托咪定 分娩镇痛 

分 类 号：R714.3[医药卫生—妇产科学]