基于文献数据挖掘分析中医药治疗畸形精子症的用药规律  

Analysis of the law of traditional Chinese medicine on teratozoospermia treatment based on literature data mining

作　　者：祝浩然 陈知絮 郝高利 靳振菲 陈玥 孙自学[2] 张宸铭[2] 张辉[2] 陈建设[2] Zhu Haoran;Chen Zhixu;Hao Gaoli;Jin Zhenfei;Chen Yue;Sun Zixue;Zhang Chenming;Zhang Hui;Chen Jianshe(Henan University of Chinese Medicine,Zhengzhou 450002,Henan,China;Henan Pronvince Hospital of Traditional Chinese Medicine,Zhengzhou 450002,Henan,China)

机构地区：[1]河南中医药大学,河南郑州450002 [2]河南省中医院,河南郑州450002

出　　处：《中国男科学杂志》2024年第1期29-36,74,共9页Chinese Journal of Andrology

基　　金：河南省自然科学基金(222300420485);河南省中医药科学研究专项课题(2022ZY1091)。

摘　　要：目的以临床文献数据为基础挖掘中医药治疗畸形精子症的临床用药规律,为临床治疗畸形精子症提供指导与方法。方法检索中国知网、万方与维普数据库,时间为建库至2022年12月31日,收集中医药治疗畸形精子症的临床资料,运用软件SPSS和Excel进行数据挖掘,总结畸形精子症的临床用药规律。结果初次检索出101篇相关文献,最终筛选出57篇临床文献,共纳入64首方剂,包含中药145种。提取出证素8种,以精亏、血瘀、湿热和阴虚为主。病位主要在肾、脾、肝,临床用药以菟丝子与枸杞子最为常见,药物类别以补虚药为主。药性集中于温、平,药味以甘为主,归经主要在肾、肝、脾经。关联规则分析显示关联强度较高的组合有8对,系统聚类分析结果分为3类,关联规则的网络可视化提示核心药物为菟丝子、枸杞子、山茱萸、熟地黄等16种,且药物间配伍关联度较高。结论畸形精子症的基本病机为精亏肾虚、湿热下注与瘀血阻络,治法以补虚、清热、利湿、活血为主。Objective To explore medication rules of traditional Chinese medicine in the treatment of teratozoospermia based on clinical literature data mining for providing guidance methods for teratozoospermia treatment.Methods Clinical literatures on teratozoospermia treatment with traditional Chinese medicine from database establishment to December 31,2022 were retrieved and collected from the database of CNKI,Wanfang and VIP.SPSS and Excel were used for data mining to summarize the clinical medication rules of teratozoospermia.Results A total of 101 related literatures were initially retrieved,and 57 clinical literatures were ultimately obtained,including 64 prescriptions containing 145 kinds of traditional Chinese medicine.Eight syndrome elements were extracted,mainly including essence deficiency,blood stasis,damp⁃heat and yin deficiency.The disease mainly located in kidney,spleen and liver.Cuscuta chinensis and Lycium barbarum were the most common clinical drugs,and the main drugs were tonic drugs.The property of the drug was warm and mild,the taste of the drug was mainly sweet,and the meridian tropism was mainly in the kidney,liver and spleen.Association rule analysis showed that there were 8 pairs of combinations with high correlation strength,and the results of hierarchical cluster analysis revealed 3 categories.The network visualization of association rules indicated that the core drugs included 16 kinds such as dodder,wolfberry fruit,cornus officinalis,prepared rehmannia root,etc.,and the compatibility correlation between drugs was high.Conclusion The basic pathogenesis of teratozoospermia is essence deficiency and kidney deficiency,damp⁃heat descending and blood stasis blocking collaterals.The main treatment is to tonify deficiency,clear heat,remove dampness and activate blood circulation.

关 键 词：畸形精子症 中药配伍 数据挖掘 中医药疗法 

分 类 号：R289.6[医药卫生—方剂学] R277.5[医药卫生—中药学]