双石通淋胶囊联合盐酸多西环素治疗男性非淋菌性尿道炎(湿热下注型)的临床研究  

Clinical efficacy of Shuangshi Tonglin capsules combined with doxycycline hydrochloride in the treatment of male non⁃gonococcal urethritis(Damp⁃Heat Pouring Downward type)

作　　者：韦一 洪志明[1,2] 陈子龙 陈文铄 王胜杰 邱俊峰 翁浩伟 Wei Yi;Hong Zhiming;Chen Zilong;Chen Wenshuo;Wang Shengjie;Qiu Junfeng;Weng Haowei(Guangzhou University of Chinese Medicine,Guangzhou 510006,Guangdong,China;The Fourth Clinical Medical College,Guangzhou University of Chinese Medicine(Shenzhen Hospital of Traditional Chinese Medicine),Shenzhen 518033,Guangdong,China)

机构地区：[1]广州中医药大学,广东广州510006 [2]广州中医药大学第四临床医学院(深圳市中医院),广东深圳518033

出　　处：《中国男科学杂志》2024年第1期115-119,共5页Chinese Journal of Andrology

基　　金：广东省深圳市中医重点专科建设项目(2019—2023年)。

摘　　要：目的观察双石通淋胶囊联合盐酸多西环素治疗男性非淋菌性尿道炎(湿热下注型)的临床疗效及安全性。方法将2022年3月至2023年3月期间,就诊的104例非淋菌性尿道炎(湿热下注型)患者依据区组随机化分为治疗组(n=52)和对照组(n=52)。对照组给予盐酸多西环素口服治疗7 d,治疗组则在此基础上联合双石通淋胶囊口服7 d。两组患者在停药后7 d进行复查。观察两组患者的临床疗效,并比较两组患者的中医症候评分、临床症状消退时间、病原体实验室检测结果和不良反应发生率。结果治疗组与对照组的总有效率分别为96.15%和84.62%,差异具有显著性(P<0.05)。治疗组的尿频、尿急、尿痛、尿道口红肿、尿道刺痒、尿道分泌物症状消退时间分别为(3.12±0.38)、(3.34±0.44)、(4.12±0.68)、(4.03±0.59)、(3.36±0.32)和(3.56±0.52)d,均优于对照组的(4.26±0.76)、(4.76±0.83)、(4.89±0.89)、(5.12±0.92)、(4.56±0.82)和(4.64±0.78)d,差异有统计学意义(P<0.05)。两组治疗后各症状评分均有所降低(P<0.05),治疗组各症状评分分别为(0.86±0.18)、(0.94±0.23)(0.79±0.16)、(1.01±0.27)、(0.83±0.20)和(0.97±0.25)分,均显著低于对照组的(1.38±0.46)、(1.54±0.52)、(1.46±0.49)、(1.50±0.51)、(1.44±0.43)和(1.32±0.36)分,差异有统计学意义(P<0.05)。治疗组病原体转阴率为96.15%,显著高于对照组的82.69%(P<0.05)。治疗组发生胃肠道反应、头痛、斑丘疹、口干例数分别为1、1、0、1例,对照组分别为1、2、2、0例,治疗组不良反应发生率为5.77%,低于对照组的9.62%,但差异无统计学意义(P>0.05)。结论双石通淋胶囊联合盐酸多西环素治疗湿热下注型男性非淋菌性尿道炎可显著提高临床病原体转阴率,有效改善临床症状,提高患者生活质量。Objective To observe the clinical efficacy and safety of Shuangshi Tonglin capsules combined with doxycycline hydrochloride in treating male non⁃gonococcal urethritis(Damp⁃Heat Pouring Downward type).Methods From March 2022 to March 2023,104 patients with non⁃gonococcal urethritis(Damp⁃Heat Pouring Downward type)were randomly divided into two groups based on block randomization,including the treatment group(n=52)and the control group(n=52).The patients in the control group were orally administrated with doxycycline hydrochloride for 7 days,and the treatment group with Shuangshi Tonglin capsules in combination with doxycycline hydrochloride for 7 days.Both groups of patients were re⁃examined at the 7th day after stopping the medication.The clinical efficacy of the two groups was observed and compared,as well as the traditional Chinese medicine symptom scores,the time of clinical symptom regression,laboratory test results for the pathogen,and the incidence of adverse reactions.Results The total efficacy rate for the treatment group and the control group was 96.15%and 84.62%,respectively,with a significant difference(P<0.05).Symptom regression times of the treatment group for frequent urination,urgency,pain,redness and swelling of the urethral opening,itching,and urethral discharge[(3.12±0.38),(3.34±0.44),(4.12±0.68),(4.03±0.59),(3.36±0.32),and(3.56±0.52)days]were all better than those of the control group[(4.26±0.76),(4.76±0.83),(4.89±0.89),(5.12±0.92),(4.56±0.82),and(4.64±0.78)days],with statistical significance(P<0.05).Symptom scores of both groups after treatment showed an obvious decrease(P<0.05),and the scores for the treatment group for each symptom[(0.86±0.18),(0.94±0.23),(0.79±0.16),(1.01±0.27),(0.83±0.20),and(0.97±0.25)]were all notably lower than those of the control group[(1.38±0.46),(1.54±0.52),(1.46±0.49),(1.50±0.51),(1.44±0.43),and(1.32±0.36)],with a significant difference(P<0.05).The pathogen clearance rate of the treatment group was 96.15%,which was higher than that

关 键 词：尿道炎 双石通淋胶囊 多西环素 湿热下注 

分 类 号：R695.2[医药卫生—泌尿科学]