包膜蛋白在痘苗病毒形态发生过程中作用的研究进展  

Research progress on role of envelope protein in morphogenesis of vaccinia virus

作　　者：王建[1] 胡紫微(综述) 郑柏松(审校) WANG Jian;HU Ziwei;ZHENG Baisong(Institute of Virology and AIDS Research,the First Hospital of Jilin University)

机构地区：[1]吉林大学第一医院艾滋病与病毒研究所,吉林长春130000

出　　处：《中国生物制品学杂志》2024年第3期376-379,384,共5页Chinese Journal of Biologicals

基　　金：吉林省自然科学基金(YDZJ202201ZYTS590)。

摘　　要：痘苗病毒(vaccinia virus,VACV)是正痘病毒属(Orthopoxvirus)成员之一,具有正痘病毒的典型特征,可作为该种属的模式病毒应用于各类研究中。VACV基因组大小约为200000 bp,包含1个高度保守的中心编码序列(central coding region sequence,CRS)区域,可编码病毒形态发生各时期的关键蛋白,其中与形态发生相关的主要包膜蛋白A13L、A17L、A27L、A28L和A36R在VACV形态发生过程中发挥重要作用。本文就包膜蛋白在VACV膜附着和膜融合、病毒粒子组装、成熟病毒粒子(intracellular mature virus,IMV)胞内运动、细胞外囊膜病毒(extracellular enveloped virus,EEV)在细胞间传播等形态发生过程中作用的研究进展作一综述,以期为进一步探讨VACV及其他正痘病毒[如猴痘病毒(monkeypox virus,MPXV)]的致病机理、研发抗病毒药物及有效预防病毒感染提供理论依据。The vaccinia virus(VACV),which belongs to the genus Orthopoxvirus,is utilized as a model virus in various studies and displays the usual traits of its kind.VACV has a genome of about 200000 bp and contains a highly conserved central coding region sequence(CRS),which can encode key proteins in various stages of virus morphogenesis.Among them,the main envelope proteins related to morphogenesis include A13L,A17L,A27L,A28L and A36R,playing an important role in the morphogenesis of VACV.In this review,the research progress on the role of envelope proteins in the morphogenesis process of VACV membrane such as attachment and membrane fusion,virus particle assembly,intracellular movement of intracellular mature virus(IMV),and intercellular transmission of extracellular enveloped virus(EEV)is reviewed,so as to provide theoretical basis for further exploring the pathogenesis of VACV and other orthopoxviruses such as monkeypox virus(MPXV),developing antiviral drugs and effectively preventing virus infection.

关 键 词：正痘病毒 痘苗病毒 包膜蛋白 形态发生 

分 类 号：R373.12[医药卫生—病原生物学]