一种改良大鼠肾移植模型的构建  

A modified method of rat kidney transplantation

作　　者：余成军 张杰 刘秩源 万永红 吴盛德[1] 华燚[1] 魏光辉[1] Yu Chengjun(Department of Urology,Children’s Hospital of Chongqing Medical University,National Clinical Research Center for Child Health and Disorders,Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering,Ministry of Education Key Laboratory of Child Development and Disorders,China International Science and Technology Cooperation Base of Child Development and Critical Disorders,Chongqing Key Laboratory of Pediatrics,Chongqing 400014,China)

机构地区：[1]重庆医科大学附属儿童医院泌尿外科,国家儿童健康与疾病临床医学研究中心,重庆市儿童泌尿生殖发育与组织工程重点实验室,儿科学重庆市重点实验室,教育部重点实验室,重庆400014

出　　处：《中华实验外科杂志》2024年第2期398-401,共4页Chinese Journal of Experimental Surgery

摘　　要：目的探索一种简单易行的大鼠肾移植模型构建方法。方法分析重庆医科大学附属儿童医院180余例同种异体大鼠肾移植模型构建中供肾获取、修剪、血管吻合及输尿管重建过程,记录手术操作要点、时间及成功率,分享改良肾移植模型构建经验。计数资料以频数(%)表示,计量资料以均数±标准差表示。结果完成180余例异体异位大鼠肾移植模型构建,成功率约85%(154/181),受体手术时间70~75 min,血管吻合时间为(25.3±3.8)min。结论改良肾移植模型易于掌握、耗时较短、成功率高、切实有效。Objective To explore a simplified and modified method of rat kidney transplantation.Methods We analyzed more than 180 heterotopic modified rat kidney transplantation models at Children’s Hospital of Chongqing Medical University,recorded operation points,operation time,and success rate,and shared our experience.Categorical variables were presented as ratios(%)and continuous variables were presented by mean±standard deviation.Results We have performed more than 180 allogenic heterotopic rat kidney transplantation procedures and gained a success rate of about 85%.The operation time of recipients was 70-75 min with vascular anastomosis time of(25.3±3.8)min.Conclusion A modified model to improve efficiency and success rate of rat kidney transplantation is established.This modified model is easy to master,with short operation time and high success rate.

关 键 词：肾移植 大鼠 改良 

分 类 号：R699.2[医药卫生—泌尿科学] R-332[医药卫生—外科学]