Theta Oscillations Support Prefrontal-hippocampal Interactions in Sequential Working Memory  

作　　者：Minghong Su Kejia Hu Wei Liu Yunhao Wu Tao Wang Chunyan Cao Bomin Sun Shikun Zhan Zheng Ye 

机构地区：[1]Institute of Psychology,Chinese Academy of Sciences,Beijing 100101,China [2]Department of Psychology,University of Chinese Academy of Sciences,Beijing 100049,China [3]Department of Neurosurgery,Center for Functional Neurosurgery,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China [4]Institute of Neuroscience,Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Shanghai 200031,China

出　　处：《Neuroscience Bulletin》2024年第2期147-156,共10页神经科学通报（英文版）

基　　金：supported by the STI2030-Major Project(2021ZD0203600);with additional support from the Shanghai Municipal Science and Technology Commission(2018SHZDZX05 and 2018ZR1406500);the Shanghai Pujiang Program(19PJ1407500);the Shanghai Jiao Tong University Medical and Engineering Cross Research Fund(YG2019QNA31);the Shanghai Municipal Health Commission Clinical Study Special Fund(20194Y0067);the Ruijin Hospital Guangci Excellence Youth Training Program(GCQN-2019-B10).

摘　　要：The prefrontal cortex and hippocampus may support sequential working memory beyond episodic memory and spatial navigation.This stereoelectroencephalography(SEEG)study investigated how the dorsolateral prefrontal cortex(DLPFC)interacts with the hippocampus in the online processing of sequential information.Twenty patients with epilepsy(eight women,age 27.6±8.2 years)completed a line ordering task with SEEG recordings over the DLPFC and the hippocampus.Participants showed longer thinking times and more recall errors when asked to arrange random lines clockwise(random trials)than to maintain ordered lines(ordered trials)before recalling the orientation of a particular line.First,the ordering-related increase in thinking time and recall error was associated with a transient theta power increase in the hippocampus and a sustained theta power increase in the DLPFC(3–10 Hz).In particular,the hippocampal theta power increase correlated with the memory precision of line orientation.Second,theta phase coherences between the DLPFC and hippocampus were enhanced for ordering,especially for more precisely memorized lines.Third,the theta band DLPFC→hippocampus influence was selectively enhanced for ordering,especially for more precisely memorized lines.This study suggests that theta oscillations may support DLPFC-hippocampal interactions in the online processing of sequential information.

关 键 词：Sequential working memory Hippocampus Dorsolateral prefrontal cortex Theta oscillations Stereoelectroencephalography(SEEG) Phase coherence Granger causality 

分 类 号：R338.64[医药卫生—人体生理学]