《外台秘要方》防治骨质疏松用药探究  

Study on Medicines for Prevention and Treatment of Osteoporosis in Waitai Miyao Fang

作　　者：徐小东 黄旭东 王卫国 XU Xiaodong;HUANG Xudong;WANG Weiguo(The First Clinical Medical College,Shandong University of Traditional Chinese Medicine,Shandong Province,Jinan 250014,China;Orthopedics Center,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Shandong Province,Jinan 250014,China)

机构地区：[1]山东中医药大学第一临床医学院,山东济南250014 [2]山东中医药大学附属医院骨伤病中心,山东济南250014

出　　处：《中国中医药现代远程教育》2024年第10期50-52,共3页Chinese Medicine Modern Distance Education of China

基　　金：国家中医药管理局全国名老中医药专家传承工作室建设项目【No.国中医药人教函〔2022〕75号】;山东省老年医学学会科技攻关计划项目【No.LKJGG2021Y043】。

摘　　要：骨质疏松是引起骨折的重要因素,易导致骨折愈合缓慢,引起肢体功能活动障碍,进而导致身体其他部位疼痛,甚至再次骨折。对《外台秘要方》第二十九章中治疗骨伤科疾病的内服方药进行归纳,发现用药频次较高的药物大部分归属于补虚药,但也不乏温里药;以上药物的有效成分大多作用于NF-κB、Wnt/β-catenin、RANKL、PI3K/Akt等信号通路,均具有抑制破骨细胞形成、增强成骨细胞活性的作用。文章从论治“骨痿”出发,参考现代药理学研究,阐释了《外台秘要方》中防治骨质疏松的药物特点。Osteoporosis is an important factor causing fractures,fracture healing easily lead to slow,causing limb dysfunction,leading to other parts of the body pain,and even fracture again.This paper summarized the internal prescriptions for the treatment of orthopedic diseases in Chapter 29 of Waitai Miyao Fang.It is found that most of the medicines with high frequency of medication belong to tonic medicines,but there is also no lack of interior-warming medicines.The active ingredients of the above medicines mostly act on NF-κB,Wnt/β-catenin,RANKL,PI3K/Akt and other signaling pathways in modern pharmacological research,all of which have the effects of inhibiting osteoclast formation and enhancing osteoblast activity.Starting from the treatment of bone flaccidity and referring to modern pharmacological research,this paper explains the characteristics of medicines for the prevention and treatment of osteoporosis in Waitai Miyao Fang.

关 键 词：骨痿 骨伤 骨质疏松 《外台秘要方》 

分 类 号：R259[医药卫生—中西医结合]