hs-CRP、HOMA-IR、SHBG与多囊卵巢综合征合并不孕症病情和预后的相关性  

Correlation between hypersensitive C-reactive protein,homeostasis model assessment of insulin resistance,sex hormone binding globulin with condition and prognosis of polycystic ovary syndrome combined with infertility

作　　者：徐晖 储成美 王德琴 徐晓英 XU Hui;CHU Chengmei;WANG Deqin;XU Xiaoying(Department of Gynaecology,People's Hospital of Hai'an City,Hai'an 226600,Jiangsu,China;Department of Endocrinology,People's Hospital of Hai'an City,Hai'an226600,Jiangsu,China)

机构地区：[1]海安市人民医院妇科,江苏海安226600 [2]海安市人民医院内分泌科,江苏海安226600

出　　处：《中国性科学》2024年第3期62-66,共5页Chinese Journal of Human Sexuality

基　　金：江苏省卫生计生委医学科研课题(H2018053)。

摘　　要：目的探讨超敏C-反应蛋白(hs-CRP)、稳态模型胰岛素抵抗指数(HOMA-IR)、性激素结合球蛋白(SHBG)与多囊卵巢综合征(PCOS)合并不孕症患者病情和预后的相关性。方法选取2020年1月至2022年2月海安市人民医院收治的158例PCOS患者作为研究对象。根据子宫内膜容受性(ERT)检测结果分为容受性良好组和容受性不良组,根据促排卵治疗1年后是否受孕分为预后良好组和预后不良组。分析影响PCOS合并不孕症的高危因素;比较不同ERT和预后的hs-CRP、HOMA-IR和SHBG水平;分析PCOS合并不孕症hs-CRP、HOMA-IR、SHBG与体重指数(BMI)、甘油三酯葡萄糖指数(TyG)和抗米勒管激素(AMH)的相关性,绘制受试者工作特征(ROC)曲线分析hs-CRP、HOMA-IR和SHBG的评估效能。结果容受性不良组的hs-CRP和HOMA-IR水平显著高于容受性良好组,SHBG水平显著低于容受性良好组(P<0.05);预后不良组的hs-CRP和HOMA-IR水平显著高于预后良好组,SHBG水平显著低于预后良好组(P<0.05)。Pearson分析显示,PCOS合并不孕症的hs-CRP、HOMA-IR与BMI、TyG呈正相关,与AMH呈负相关(P<0.05);SHBG与AMH呈正相关,与BMI、TyG呈负相关(P<0.05)。ROC曲线显示,hs-CRP、HOMA-IR和SHBG联合诊断PCOS合并不孕症的曲线下面积、灵敏度、特异度均高于任一单项效能(P<0.05)。结论hs-CRP、HOMA-IR和SHBG联合检测对PCOS合并不孕症的病情和预后的评估价值较高。Objective To investigate the correlation between hypersensitive C-reactive protein(hs-CRP),homeostasis model assessment of insulin resistance(HOMA-IR)and sex hormone binding globulin(SHBG)with the condition and prognosis of polycystic ovary syndrome(PCOS)with infertility patients.Methods A total of 158 PCOS patients admitted to People's Hospital of Hai'an City from January 2020 to February 2022 were selected as the study objects.According to endometrial receptivity(ERT)test results they were divided into good receptivity group and poor receptivity group,according to whether pregnancy was achieved 1 year after ovulation induction treatment they were divided into good prognosis group and poor prognosis group.To analyze the high-risk factors affecting infertility caused by PCOS.The levels of hs-CRP,HOMA-IR and SHBG of different ERT and prognosis were compared.The correlation between hs-CRP,HOMA-IR and SHBG with body mass index(BMI),triacylglycerol glucose index(TyG)and anti-Müllerian hormone(AMH)in PCOS combined with infertility was analyzed,and the evaluation efficacy of hs-CRP,HOMA-IR and SHBG was analyzed by drawing receiver operating characteristics(ROC)curve.Results The levels of hs-CRP and HOMA-IR in poor receptivity group were significantly higher than those in good receptivity group,and the level of SHBG was significantly lower than that in good receptivity group(P<0.05).The hs-CRP and HOMA-IR levels in the poor prognosis group were significantly higher than those in the good prognosis group,and the SHBG level was significantly lower than that in the good prognosis group(P<0.05).Pearson analysis showed that hs-CRP and HOMA-IR were positively correlated with BMI and TyG in PCOS combined with infertility,and negatively correlated with AMH(P<0.05).SHBG was positively correlated with AMH,and negatively correlated with BMI and TyG(P<0.05).ROC curve showed that the area under curve,sensitivity and specificity of the combined diagnosis of hs-CRP,HOMA-IR and SHBG in PCOS combined with infertility were higher than a

关 键 词：多囊卵巢综合征 不孕症 超敏C-反应蛋白 稳态模型胰岛素抵抗指数 性激素结合球蛋白 评估价值 

分 类 号：R711[医药卫生—妇产科学]