健脾利湿解毒方内外兼治宫颈锥切术后持续HPV感染的临床效果研究  

Clinical effect of Jianpi Lishi Jiedu Decoction for internal and external treatment on persistent human papilloma virus infection after cervical conization

作　　者：倪雅丽 颛佳 赵云彦 孙佳 陈瑞雪 邵迎华 杨秀梅 NI Yali;ZHUAN Jia;ZHAO Yunyan;SUN Jia;CHEN Ruixue;SHAO Yinghua;YANG Xiumei(Department of Gynecology,Cangzhou People's Hospital,Cangzhou 061000,Hebei,China;Department of Traditional Chinese Medicine,Cangzhou People's Hospital,Cangzhou 061000,Hebei,China)

机构地区：[1]沧州市人民医院妇科,河北沧州061000 [2]沧州市人民医院中医科,河北沧州061000

出　　处：《中国性科学》2024年第3期117-121,共5页Chinese Journal of Human Sexuality

基　　金：河北省中医药管理局科研项目(2023456)。

摘　　要：目的探讨健脾利湿解毒方内外兼治宫颈锥切术后持续人乳头瘤病毒(HPV)感染的临床效果。方法选取2021年1月至2022年12月沧州市人民医院收治的104例宫颈锥切术后持续HPV感染患者作为研究对象,按照随机数字表法分为对照组和观察组,各52例。对照组以重组人干扰素α-2b阴道泡腾片治疗,观察组增加健脾利湿解毒方内外兼治。3个疗程后,比较两组临床疗效、中医证候积分、炎症因子、免疫功能、治疗安全性。结果观察组总有效率为92.31%(48/52),高于对照组的76.92%(40/52),差异具有统计学意义(P<0.05)。观察组各项中医证候积分均低于对照组(P<0.05)。观察组沉默调节蛋白1(SIRT1)、Nod样受体蛋白3(NLRP3)、基质金属蛋白酶组织抑制因子-3(TIMP-3)低于对照组(P<0.05)。观察组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)高于对照组,CD8^(+)低于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论健脾利湿解毒方内外兼治宫颈锥切术后持续HPV感染临床效果显著,可促进HPV转阴,改善中医证候,抑制炎症因子表达,提升免疫水平,安全性良好。Objective To discuss the clinical effect of Jianpi Lishi Jiedu Decoction for internal and external treatment on persistent human papilloma virus(HPV)infection after cervical conization.Methods total of 104 patients with persistent HPV infection after cervical conization admitted to Cangzhou People's Hospital from January 2021 to December 2022 were selected as study objects,and randomly divided into control group and observation group using a number table method,with 52 patients in each group.The control group was treated with recombinant human interferonα-2b vaginal effervescent tablets,and the observation group was treated with Jianpi Lishi Jiedu Decoction for internal and external treatment.After three courses of treatment,the clinical efficacy,traditional Chinese medicine(TCM)syndrome scores,inflammatory factors,immune function,and treatment safety of the two groups were compared.Results The total effective rate of the observation group was 92.31%(48/52),which was higher than 76.92%(40/52)of the control group(P<0.05).The scores of each item of TCM syndrome scores in the observation group were lower than those in the control group(P<0.05).Silent information regulator 1(SIRT1),Nod-like receptor thermal protein domain associated protein 3(NLRP3)and tissue inhibitor of metalloproteinase 3(TIMP-3)in the observation group were lower than those in the control group(P<0.05).The CD3^(+),CD4^(+),CD4^(+)/CD8^(+)in the observation group were higher than those in the control group,while CD8^(+)were lower than those in the control group(P<0.05).There was no significant difference in incidence rates of adverse reactions between the two groups(P>0.05).Conclusions Jianpi Lishi Jiedu Decoction has significant clinical effect in internal and external treatment on persistent HPV infection after cervical conization is significant.It can promote HPV negative transformation,improve TCM symdrome,inhibit the expression of inflammatory factors,and enhance immune level,with good safety.

关 键 词：人乳头瘤病毒 宫颈锥切术 健脾利湿解毒方 内外兼治 中医证候 

分 类 号：R711[医药卫生—妇产科学]