血清正五聚蛋白3、富亮氨酸α-2-糖蛋白1水平变化与尖锐湿疣复发的关系  

Relationship between changes in serum pentraxin-3,leucine-richα-2-glycoprotein 1 levels and recurrence of condyloma acuminatum

作　　者：罗红玉 陈柳青[1] LUO Hongyu;CHEN Liuqing(Department of Dermatology,Wuhan First Hospital,Wuhan 430022,Hubei,China)

机构地区：[1]武汉市第一医院皮肤科,武汉430022

出　　处：《中国性科学》2024年第3期144-148,共5页Chinese Journal of Human Sexuality

基　　金：2021年度武汉市卫生健康委科研项目(WZ21Q20)。

摘　　要：目的探讨血清正五聚蛋白3(PTX3)、富亮氨酸α-2-糖蛋白1(LRG1)水平变化与尖锐湿疣(CA)复发的关系。方法选取2020年1月至2022年1月武汉市第一医院收治的120例CA患者(CA组)作为研究对象。根据患者治疗后复发情况进一步分为复发组(n=64)和无复发组(n=56)。选取同期健康体检者120例设为对照组。采用酶联免疫吸附试验法检测血清PTX3、LRG1水平。采用多因素Logistic回归分析CA患者复发的影响因素。采用受试者工作特征(ROC)曲线评价血清PTX3、LRG1及其联合对CA患者复发的预测效能。结果CA组PTX3、LRG1水平显著高于对照组(P<0.05)。与无复发组比较,复发组熬夜、避孕套使用、性伴侣人乳头瘤病毒(HPV)感染人数及白介素(IL)-6、IL-1β、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、PTX3、LRG1水平显著较高(P<0.05)。Logistic分析结果显示,IL-6、IL-1β、TNF-α、CRP、PTX3、LRG1均是CA复发的独立危险因素(P<0.05)。CA患者血清PTX3与LRG1呈正相关(r=0.680,P<0.05),PTX3与IL-6、IL-1β、TNF-α、CRP呈正相关(r=0.587、0.523、0.592、0.566,P<0.05),LRG1与IL-6、IL-1β、TNF-α、CRP呈正相关(r=0.547、0.508、0.559、0.531,P<0.05)。ROC曲线结果显示,血清PTX3、LRG1水平及二者联合预测CA复发的曲线下面积(AUC)分别为0.742、0.795、0.878,其中联合预测的AUC显著高于二者单独预测(Z=2.490、1.615,P<0.05)。结论CA患者血清PTX3、LRG1水平显著上升,其可增加CA复发的风险,均可作为CA复发的预测因子。Objective To investigate the relationship between changes in serum pentraxin-3(PTX3),leucine-rich α-2-glycoprotein 1(LRG1)levels and recurrence of condyloma acuminatum(CA)and their predictive value for recurrence.Methods A total of 120 CA patients(CA group)admitted to Wuhan First Hospital were selected as study objects.They were further divided into recurrence group(n=64)and non-recurrence group(n=56)based on their recurrence condition after treatment.Another 120 patients with physical examination during the same period were selected as the control group.The levels of serum PTX3 and LRG1 were detected by enzyme-linked immunosorbent assay.Multivariable Logistic regression was applied to analyze the influencing factors of recurrence in CA patients.Receiver operating characteristic(ROC)curve was applied to evaluate the predictive efficacy of serum PTX3,LRG1 and their combination on the recurrence of CA patients.Results The levels of PTX3 and LRG1 in CA group were significantly higher than those in control group(P<0.05).Compared with the non-recurrence group,the recurrence group had significantly higher numbers in staying up late,condom use,sexual partners infected by human papillomavirus(HPV),and the levels of interleukin(IL)-6,IL-1β,tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),PTX3 and LRG1(P<0.05).Logistic analysis result showed that IL-6,IL-1β,TNF-α,CRP,PTX3 and LRG1 were all independent risk factors for CA recurrence(P<0.05).PTX3 in serum of CA patients was positively correlated with LRG1(r=0.680,P<0.05),and with IL-6 and IL-1β,TNF-α,CRP(r=0.587,0.523,0.592,0.566,P<0.05).LRG1 was positively correlated with IL-6,IL-1β,TNF-α,CRP(r=0.547,0.508,0.559,0.531,P<0.05).The ROC curve results showed that the area under curve(AUC)of serum PTX3,LRG1 and combined prediction of CA reccurence was 0.742,0.795 and 0.878 respectively,and the AUC of the combination prediction was significantly higher than that predicted by the two alone(Z=2.490,1.615,P<0.05).Conclusions The serum PTX3 and LRG1 levels in patients

关 键 词：尖锐湿疣 正五聚蛋白3 富亮氨酸α-2-糖蛋白1 复发 预测价值 

分 类 号：R759[医药卫生—皮肤病学与性病学]